Document Detail

Reproductive hormones and blood pressure during pregnancy.
MedLine Citation:
PMID:  11139529     Owner:  NLM     Status:  MEDLINE    
The mechanisms involved in cardiovasular changes during human pregnancy and the complicated aetiology of gestational hypertension are unclear. Reproductive hormones have known effects on the cardiovascular system in the non-pregnant state and in animal systems, but their effects in human pregnancy are uncertain. In this study of pregnant women, the effects of serum concentrations of relaxin, progesterone and oestradiol on arterial blood pressure were studied. Higher serum concentrations of progesterone and relaxin, but not oestradiol, in early pregnancy were related to lower mean systolic blood pressures in the second and third trimesters. No relationship was found between hormonal concentrations and diastolic blood pressures. However, women with a diastolic blood pressure of >90 mmHg in late pregnancy showed statistically significant lower relaxin concentrations in early pregnancy in comparison with women whose diastolic blood pressure was </=90 mmHg. In a multivariate analysis, the mean systolic blood pressure (P: < 0.0001) and serum relaxin (P: < 0.01) in early pregnancy, but not progesterone, were independently related to systolic blood pressure in late pregnancy. The results support previous experimental and clinical studies. The effect of relaxin may be explained by a possible vasodilatatory action seen in animal studies and appears to be moderate.
P Kristiansson; J X Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  16     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-17     Citation Subset:  IM    
Uppsala University, Section of Family Medicine, Department of Public Health and Caring Sciences, University Hospital, S-751 85 Uppsala, Sweden.
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MeSH Terms
Blood Pressure*
Estradiol / blood
Hormones / blood*
Pregnancy / blood*,  physiology*
Progesterone / blood
Relaxin / blood
Time Factors
Reg. No./Substance:
0/Hormones; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-69-1/Relaxin
Comment In:
Hum Reprod. 2001 Aug;16(8):1777   [PMID:  11473981 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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