Document Detail

Reproductive health of adolescent girls perinatally infected with HIV.
MedLine Citation:
PMID:  17463385     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to describe the reproductive health of adolescent girls perinatally infected with HIV.
METHODS: We estimated the incidence of first pregnancy, genital infections, and abnormal cervical cytology for 638 girls aged 13 years and older in the Pediatric AIDS Clinical Trials Group protocol 219C.
RESULTS: Thirty-eight girls became pregnant, for a first pregnancy rate of 18.8/1000 person-years; 7 of these girls had additional pregnancies (95% confidence interval [CI]=13.3, 25.7). Thirty-two pregnancies resulted in live births. All girls received antiretroviral therapy during pregnancy. One infant was HIV infected, 29 were uninfected, and 2 had unknown infection status, for a rate of mother-to-child transmission of HIV in infants with known infection status of 3.3% (95% CI=0.1, 18.6). Condylomata and trichomoniasis were the most frequent genital infections. Forty-eight (47.5%) of 101 girls with Papanicolaou test examinations had abnormal cervical cytology, including atypical cells of undetermined significance (n=18), low-grade squamous intraepithelial lesions (SIL; n=27), and high-grade SIL (n=3). Many abnormalities persisted despite intervention.
CONCLUSIONS: Pregnancy rates were lower and cervical abnormalities were higher than among non-HIV-infected adolescents. These findings underscore the importance of Papanicolaou tests and promotion of safer sexual practices in this population.
Susan B Brogly; D Heather Watts; Nathalie Ylitalo; Eduardo L Franco; George R Seage; James Oleske; Michelle Eagle; Russell Van Dyke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-26
Journal Detail:
Title:  American journal of public health     Volume:  97     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-06-27     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1047-52     Citation Subset:  AIM; IM    
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Mass 02115-6017, USA.
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MeSH Terms
Cervical Intraepithelial Neoplasia / epidemiology,  virology
Chi-Square Distribution
HIV Infections / epidemiology,  transmission*
Health Promotion
Health Status Indicators*
Infectious Disease Transmission, Vertical / statistics & numerical data*
Papillomavirus Infections / epidemiology,  virology
Pregnancy in Adolescence / statistics & numerical data*
Risk Factors
Sexual Behavior
Statistics, Nonparametric
Tumor Virus Infections / epidemiology,  virology
Uterine Cervical Neoplasms / epidemiology,  virology
Vaginal Smears / statistics & numerical data
Grant Support
Comment In:
Am J Public Health. 2007 Nov;97(11):1929-30; author reply 1930   [PMID:  17901419 ]

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