| Reproductive function and outcome of pregnancy after liver transplantation in women. | |
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MedLine Citation:
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PMID: 7898148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To discuss menstrual function before and after liver transplantation, immunosuppression during pregnancy, outcome and management of pregnancy, and use of contraception in women after liver transplantation. MATERIAL AND METHODS: We review the relevant medical literature and describe our clinical experience in the management of gynecologic and obstetric issues in recipients of liver transplants. RESULTS: Menstrual abnormalities, such as amenorrhea, oligomenorrhea, irregular bleeding, and metrorrhagia, are common in women with liver disease and may often be the first clinical indication of liver dysfunction. Normal menstrual function is frequently restored after transplantation. Successful pregnancies have occurred in recipients of liver transplants, but such pregnancies are often complicated by preterm delivery, preeclampsia, and infection. Use of immunosuppressive medications should be maintained during pregnancy, and drug concentrations should be carefully monitored; none has been found to be teratogenic. Pregnancy does not seem to accelerate graft rejection. Barrier contraception or sterilization, if appropriate, seems to be the safest option for these patients. CONCLUSION: Because liver transplantation leads to restoration of normal menstruation, female patients of reproductive age must be counseled about the possibility of pregnancy and the use of contraception. Pregnancy should be avoided for at least the first 6 months after transplantation. With specialized care and attention, pregnancies are generally associated with good outcomes. |
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Authors:
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S A Laifer; R S Guido |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 70 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-04-21 Completed Date: 1995-04-21 Revised Date: 2007-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 388-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, Pittsburgh, PA 15213. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Contraception Female Humans Immunosuppression* Liver Diseases / physiopathology, surgery Liver Transplantation* Menstruation / physiology* Pregnancy Pregnancy Outcome* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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