Document Detail

Reproductive function after liver transplantation.
MedLine Citation:
PMID:  15562579     Owner:  NLM     Status:  MEDLINE    
Successful pregnancy outcomes are possible after liver transplantation. Although there are risks to the mother and fetus, there has not been an increased incidence of malformations noted in the newborn of liver recipients. Close, coordinated care involving the hepatologist, surgeon, and high-risk obstetrician is essential to ensure a favorable outcome. Immunosuppression peripartum should be maintained at appropriate levels. Of note, a small subset of recipients may suffer worsened graft function during pregnancy. Recurrent liver disease, especially viral hepatitis, and CMV infection appear to pose significant risks to mother and offspring, respectively, although the magnitude of the risks is unknown. It therefore would seem prudent to consider pregnancy only in female liver recipients who have passed at least 1 year with stable graft function. In addition, new immunosuppressive regimens further add to the lack of information regarding pregnancy safety. The NTPR is an ongoing database to collect information and pregnancy outcomes. That information should be helpful in counseling recipients and in pregnancy management.
V T Armenti; S K Herrine; M J Moritz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in liver disease     Volume:  1     ISSN:  1089-3261     ISO Abbreviation:  Clin Liver Dis     Publication Date:  1997 Aug 
Date Detail:
Created Date:  2004-11-25     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  471-85     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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MeSH Terms
Cytomegalovirus Infections / etiology,  prevention & control
Immunosuppressive Agents / pharmacology
Liver Cirrhosis / complications,  physiopathology*,  surgery*
Liver Transplantation* / adverse effects
Menstruation / physiology*
Pregnancy Complications, Infectious / etiology,  prevention & control
Pregnancy Outcome*
Sexual Dysfunction, Physiological / complications
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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