| Reproductive endocrine disruption in the freshwater catfish, Heteropneustes fossilis, in response to the pesticide gamma-hexachlorocyclohexane. | |
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MedLine Citation:
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PMID: 15087166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both male and female freshwater catfish, Heteropneustes fossilis, were exposed to safe (SC; 0.1 and 1.0 mg/L) and sublethal (SL; 10 mg/L) concentrations of an agricultural pesticide, gamma-hexachlorocyclohexane (gamma-HCH) for 4 weeks during the active pre-spawning (vitellogenic) phase of their annual reproductive cycle. On the last day of exposure, 18 h before killing, fish were treated intramuscularly (i.m.) with [I-14C]acetic acid (74 kBq per fish). After 4 weeks of exposure, we monitored the effects of gamma-HCH on gonadosomatic index (GSI); on plasma concentrations of gonadotropin (GtH), testostosterone (T), 11-ketotestosterone (11-KT), 17beta-estradiol (E2); and on hepatic incorporation of [I-14C]acetic acid into total phospholipids (TP) and the fractions thereof: phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylinositol (PI), and phosphatidylethanolamine (PE). In both the sexes, GSI and plasma GtH were decreased significantly in response to gamma-HCH exposure. Plasma T and 11-KT in males, and plasma T and E2 in females declined significantly in response to gamma-HCH exposure. In both the sexes, hepatic incorporation of [I-14C]acetic acid into PS and PI increased significantly, whereas incorporation into TP, PC, and PE was significantly reduced after gamma-HCH exposure. Our findings demonstrated that gamma-HCH exposure depressed GSI, plasma GtH, sex steroids, and [I-14C]acetic acid incorporation into hepatic TP, and had very selective and specific effects on various classes of TP, resulting either from the hypothalamo-hypophyseal-gonadal axis or from direct action on hepatic and steroidogenic enzymes during the pre-spawning phase, causing reproductive endocrine disruptions. |
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Authors:
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Pratap B Singh; Adelino V M Canario |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 58 ISSN: 0147-6513 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-16 Completed Date: 2004-08-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 77-83 Citation Subset: IM |
Affiliation:
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Department of Zoology, Tilak Dhari College, Jaunpur 222002, India. pratap_p_singh@rediffmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catfishes / physiology* Endocrine System / drug effects* Environmental Exposure* Female Gonadal Steroid Hormones / blood* Gonads / growth & development Hypothalamo-Hypophyseal System / drug effects, physiology Insecticides / toxicity* Lindane / toxicity* Male Phospholipids / analysis Water Pollutants, Chemical / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones; 0/Insecticides; 0/Phospholipids; 0/Water Pollutants, Chemical; 58-89-9/Lindane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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