| Reproductive and developmental toxicity of metals. | |
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MedLine Citation:
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PMID: 4035317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper discusses metal exposure in the male, the nonpregnant female, and the maternal-offspring unit. In the first two situations, the primary targets are the gonads. In the mother-offspring unit, consideration must be given to effects on the fertilized ovum, the growth of the embryo, and, finally, to the fetal and perinatal stages. The central nervous system may be especially vulnerable during development. The placenta also undergoes development, and either the placenta or the fetus may be the primary target. In humans, certain metals may cause abortion or other effects on the conceptus. Effects may also be produced by metal exposure both in utero and in the suckling infant. For example, methylmercury gives rise to a range of effects on the central nervous system at doses lower than those producing damage to the mature nervous system. Effects of lead and arsenic are associated mainly with postnatal exposures during infancy and early childhood, but there is reason to believe from animal experiments that some effects may occur from prenatal exposures to certain metal compounds. |
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Authors:
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T W Clarkson; G F Nordberg; P R Sager |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of work, environment & health Volume: 11 ISSN: 0355-3140 ISO Abbreviation: Scand J Work Environ Health Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-10-09 Completed Date: 1985-10-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7511540 Medline TA: Scand J Work Environ Health Country: FINLAND |
Other Details:
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Languages: eng Pagination: 145-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Suckling Arsenic / metabolism, pharmacology, toxicity Cadmium / metabolism, pharmacology, toxicity Chromium / metabolism, pharmacology, toxicity Embryonic and Fetal Development / drug effects* Female Fetus / metabolism Humans Infant, Newborn Lead / metabolism, pharmacology Lead Poisoning / complications Mercury / metabolism, pharmacology, toxicity Metals / metabolism, pharmacology, toxicity* Methylmercury Compounds / metabolism, pharmacology, toxicity Nickel / metabolism, pharmacology, toxicity Pregnancy Reproduction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Methylmercury Compounds; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-02-0/Nickel; 7440-38-2/Arsenic; 7440-43-9/Cadmium; 7440-47-3/Chromium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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