Document Detail


Reproductive consequences of developmental phytoestrogen exposure.
MedLine Citation:
PMID:  22223686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phytoestrogens, estrogenic compounds derived from plants, are ubiquitous in human and animal diets. These chemicals are generally much less potent than estradiol but act via similar mechanisms. The most common source of phytoestrogen exposure to humans is soybean-derived foods that are rich in the isoflavones genistein and daidzein. These isoflavones are also found at relatively high levels in soy-based infant formulas. Phytoestrogens have been promoted as healthy alternatives to synthetic estrogens and are found in many dietary supplements. The aim of this review is to examine the evidence that phytoestrogen exposure, particularly in the developmentally sensitive periods of life, has consequences for future reproductive health.
Authors:
Wendy N Jefferson; Heather B Patisaul; Carmen J Williams
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review     Date:  2012-01-05
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  143     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-07-24     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-60     Citation Subset:  IM    
Affiliation:
Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH/DHHS, MD E4-05, Research Triangle Park, North Carolina 27709, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Child Development / drug effects*
Diet
Humans
Infant
Infant Food / adverse effects
Infant Formula / chemistry
Infant, Newborn
Phytoestrogens / adverse effects,  pharmacology*
Reproduction / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
R01-ES016001/ES/NIEHS NIH HHS; Z01-ES102405/ES/NIEHS NIH HHS; ZIA ES102405-04/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Phytoestrogens
Comments/Corrections

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