Document Detail

Reproductive characteristics of Mastomys natalensis and Lassa virus prevalence in Guinea, West Africa.
MedLine Citation:
PMID:  18237265     Owner:  NLM     Status:  MEDLINE    
We recently reported increased prevalence of Lassa virus (LASV) infection in Mastomys natalensis during the rainy season in Guinea, West Africa. Here, the association of LASV prevalence with fecundity, fertility, and the age structure of the rodent population was analyzed using data from the previous study. The animals reproduced throughout the year, but highest fecundity was observed during the rainy season. Accordingly, the rodent population was aged at the beginning and young at the end of the rainy season. Lassa virus infection was observed in all age groups, including the very young, which is compatible with vertical transmission. However, since the prevalence of infection showed a trend with increasing age in the younger age groups, horizontal transmission by yet unknown mechanisms may also play a role in LASV transmission. Multivariate analysis did not show an association of LASV prevalence with any demographic variable studied. Rodent behavior influencing virus transmissibility and contaminated environment may therefore be responsible for spatial and seasonal variations in LASV prevalence in M. natalensis.
Elisabeth Fichet-Calvet; Emilie Lecompte; Lamine Koivogui; Stéphane Daffis; Jan ter Meulen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vector borne and zoonotic diseases (Larchmont, N.Y.)     Volume:  8     ISSN:  1530-3667     ISO Abbreviation:  Vector Borne Zoonotic Dis.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-07-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100965525     Medline TA:  Vector Borne Zoonotic Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Department of Systematics and Evolution, Museum National d'Histoire Naturelle, Paris, France.
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MeSH Terms
Age Factors
Body Weight / physiology
Disease Reservoirs / veterinary,  virology
Disease Transmission, Infectious / veterinary
Guinea / epidemiology
Infectious Disease Transmission, Vertical / veterinary
Lassa Fever / epidemiology,  transmission,  veterinary*
Lassa virus / isolation & purification*
Multivariate Analysis
Murinae / physiology*,  virology*
Reproduction / physiology*
Rodent Diseases / epidemiology*,  transmission

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