| Reproductive assessment of hydroalcohol extract of Calendula officinalis L. in Wistar rats. | |
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MedLine Citation:
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PMID: 19288530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was conducted to evaluate the effects of the administration of a hydroalcohol extract of Calendula officinalis L. flowers (HAE) on the reproductive function of Wistar rats. Four groups of adult male rats were treated orally with HAE at doses of 0, 0.25, 0.5 and 1.0 g/kg for 60 consecutive days. From day 53 to 60 of treatment, rats were mated with untreated and fertile female rats. Reproductive parameters including testicular morphology, reproductive organ weights, fertility index and offspring viability were evaluated. In another protocol, groups of pregnant rats were treated orally with the same doses of HAE from days 1 to 6 (preimplantation period), 7 to 14 (organogenic period) or 15 to 19 (fetal period) of pregnancy. On day 20 of pregnancy, rats were killed for evaluation of maternal and fetal parameters. The results showed that the treatment with HAE did not affect male reproductive parameters. Besides, it was non-toxic in the preimplantation and organogenic periods of pregnancy. However, the HAE induced a decrease of the maternal weight gain when administered during the fetal period. In conclusion, the HAE did not affect male fertility nor had toxic effects in early and middle periods of pregnancy. However, the HAE caused maternal toxicity when administered during the fetal period of pregnancy. |
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Authors:
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Erick J R Silva; Jo??o H Costa-Silva; Liriane B Ev??ncio; Maria do Carmo C A Fraga; Maria Cristina O C Coelho; Almir G Wanderley |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1392-8 Citation Subset: IM |
Copyright Information:
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(c) 2009 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife-PE, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calendula / toxicity* Drug Administration Schedule Female Fertility / drug effects Flowers Male Organ Size / drug effects Plant Extracts / toxicity* Pregnancy Pregnancy, Animal / drug effects* Rats Rats, Wistar Reproduction / drug effects* Testis / drug effects Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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