| Reproducibility and validity of lung density measures from cardiac CT Scans--The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. | |
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MedLine Citation:
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PMID: 19427979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: Cardiac computed tomographic (CT) scans for the assessment of coronary calcium scores include approximately 70% of the lung volume and may be useful for the quantitative assessment of emphysema. The reproducibility of lung density measures from cardiac computed tomography and their validity compared to lung density measures from full-lung scans is unknown. MATERIALS AND METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) performed paired cardiac CT scans for 6814 participants at baseline and at follow-up. The MESA-Lung Study assessed lung density measures in the lung fields of these cardiac scans, counting voxels below -910 HU as moderate-to-severe emphysema-like lung regions. We evaluated: 1) the reproducibility of lung density measures among 120 randomly selected participants; 2) the comparability of measures acquired on electron beam CT (EBCT) and multidetector CT (MDCT) scanners among 10 participants; and 3) the validity of these measures compared to full-lung scans among 42 participants. Limits of agreement were determined using Bland-Altman approaches. RESULTS: Percent emphysema measures from paired cardiac scans were highly correlated (r = 0.92-0.95) with mean difference of -0.05% (95% limits of agreement: -8.3, 8.4%). Measures from EBCT and MDCT scanners were comparable (mean difference -0.9%; 95% limits of agreement: -5.1, 3.3%). Percent emphysema measures from MDCT cardiac and MDCT full-lung scans were highly correlated (r = 0.93) and demonstrated reasonable agreement (mean difference 2.2%; 95% limits of agreement: -9.2, 13.8%). CONCLUSIONS: Although full-lung imaging is preferred for the quantification of emphysema, the lung imaging from paired cardiac computed tomography provided a reproducible and valid quantitative assessment of emphysema in a population-based sample. |
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Authors:
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Eric A Hoffman; Rui Jiang; Heather Baumhauer; Michael A Brooks; J Jeffrey Carr; Robert Detrano; Joseph Reinhardt; Josanna Rodriguez; Karen Stukovsky; Nathan D Wong; R Graham Barr |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Academic radiology Volume: 16 ISSN: 1878-4046 ISO Abbreviation: Acad Radiol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-07-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 689-99 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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statistics & numerical data* Comorbidity Coronary Artery Disease / ethnology*, radiography* Emphysema / ethnology*, radiography* Female Humans Incidence Male Middle Aged Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / statistics & numerical data* United States / ethnology |
| Grant Support | |
ID/Acronym/Agency:
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N01 HC095159/HC/NHLBI NIH HHS; N01 HC095165/HC/NHLBI NIH HHS; N01 HC095169/HC/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01 HL-075476/HL/NHLBI NIH HHS; R01 HL-077612/HL/NHLBI NIH HHS; R01 HL064368-09/HL/NHLBI NIH HHS; R01 HL075476-01/HL/NHLBI NIH HHS; R01 HL077612-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Acad Radiol. 2010 Mar;17(3):399; author reply 399-401
[PMID:
20152729
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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