| Reproducibility and validation of tumour stroma ratio scoring on oesophageal adenocarcinoma biopsies. | |
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MedLine Citation:
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PMID: 21036599 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Tumour stroma ratio (TSR) in histological sections of resected oesophageal adenocarcinomas proved to be a prognostic factor for patients' survival. The objectives of this study were to assess inter- and intraobserver agreement for TSR scoring on biopsy material and to validate these biopsy results with the results derived from surgical specimens. METHODS: Biopsies and surgical specimens of 91 patients with oesophageal adenocarcinoma were available. TSR was determined on the original haematoxylin-eosin (H&E) tissue sections from primary tumour biopsies. To assess interobserver variation, TSR was scored by three pathologists as 0-25%, 25-50%, 50-75% or 75-100%. A second scoring was done to examine intraobserver variation. The definitive TSR biopsy score was compared with the corresponding resection specimen score. Kappa statistics were applied to evaluate agreement. RESULTS: Biopsies of 10 (11%) patients were rejected because of poor quality. For 81 TSR biopsy scores, interobserver correlations ranged between 0.239 and 0.486 (P<0.001 for all). By classifying scores into two groups (<50% and ⩾50%), interobserver correlations ranged between 0.372 and 0.886 (P<0.001 for all). Intraobserver agreement was substantial to near-perfect (κ=0.780-0.848; P<0.001 for all). Definitive TSR biopsy score showed moderate correlation with TSR scores on surgical specimens (κ=0.506), but it was an independent prognostic factor for survival. CONCLUSION: Reproducibility of tumour stroma ratio scoring on oesophageal adenocarcinoma biopsies was good. The ease of TSR scoring on H&E sections together with its correlation with patients' survival may have clinical relevance in this era of neoadjuvant therapy. |
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Authors:
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Ewout F W Courrech Staal; Vincent T H B M Smit; Marie-Louise F van Velthuysen; Juliette M J Spitzer-Naaykens; Michel W J M Wouters; Wilma E Mesker; Rob A E M Tollenaar; Johanna W van Sandick |
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Publication Detail:
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Type: Journal Article Date: 2010-10-29 |
Journal Detail:
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Title: European journal of cancer (Oxford, England : 1990) Volume: 47 ISSN: 1879-0852 ISO Abbreviation: Eur. J. Cancer Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005373 Medline TA: Eur J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 375-82 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Surgical Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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