Document Detail

Reproducibility of three classification systems of ductal carcinoma in situ of the breast using a web-based survey.
MedLine Citation:
PMID:  20663616     Owner:  NLM     Status:  MEDLINE    
This study assessed the degree of diagnostic agreement among pathologists between three classification systems of ductal carcinoma in situ of the breast (DCIS). Thirteen pathologists received the same set of digitized images of microscopy of 43 DCIS cases and answered a questionnaire containing the criteria to compose the three classification systems studied: Holland, modified Lagios, and Van Nuys. A computer program was created, which organizes the information collected from each pathologist, supplying the histological grading of the cases within the three classification systems. The results were analyzed using percental agreement and the Kappa test. Diagnostic agreement for the three DCIS of the breast classification systems presented K values that varied from 0.27 to 0.37. Among the three classifications used, most agreement was for Van Nuys, showing a Kappa index of 0.37. These results matched the interobserver agreements, with Kappa indices varying from 0.13 to 0.64 for the Holland classification; 0.23 to 0.61 for the modified Lagios classification; and 0.23 to 0.74 for the Van Nuys classification. Pathologists specialized in breast pathology showed greater reproducibility for all the criteria evaluated. Comparing the three classification systems, diagnostic agreement and accuracy were rated higher for the classification of Van Nuys compared to modified Lagios and Holland.
Fernando Schuh; Jorge Villanova Biazús; Erika Resetkova; Camila Zanella Benfica; Maria Isabel Albano Edelweiss
Related Documents :
2174576 - Breast cancer: the military's experience at wilford hall usaf medical center.
9496256 - Simultaneous loss of e-cadherin and catenins in invasive lobular breast cancer and lobu...
20013346 - Clinicopathologic characteristics of pleomorphic carcinoma of the breast.
7393516 - Treatment of carcinoma in situ of the vulva with topical 5-fluorouracil.
21603256 - The characterization of cell line crl-2335 as a basal-like breast carcinoma model.
12394676 - Discrimination of benign from malignant prostatic disease by selective measurements of ...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-07-21
Journal Detail:
Title:  Pathology, research and practice     Volume:  206     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  705-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breast Neoplasms / classification,  diagnosis*,  pathology
Carcinoma, Intraductal, Noninfiltrating / classification,  diagnosis*,  pathology
Health Care Surveys
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Terminology as Topic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Desmin and troponin T are degraded faster in type IIb muscle fibers than in type I fibers during pos...
Next Document:  Microbial communities in the tonsils of healthy pigs.