| Reproducibility of serial whole-brain MR spectroscopic imaging. | |
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MedLine Citation:
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PMID: 19777506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The reproducibility of serial measurements using a volumetric proton MR Spectroscopic Imaging (MRSI) acquisition implemented at 3 Tesla and with lipid suppression by inversion-recovery has been evaluated. Data were acquired from two subjects at five time points, and processed using fully-automated procedures that included rigid registration between studies. These data were analyzed to determine coefficients of variance (COV) for each metabolite and for metabolite ratio images based on an individual voxel analysis, as well as for average and grey-matter and white-matter values from atlas-defined brain regions. The volumetric MRSI acquisition was found to obtain data of sufficient quality for analysis over 70 +/- 6% of the total brain volume, and spatial distributions of the resultant COV values were found to reflect the known distributions of susceptibility-induced magnetic field inhomogeneity. Median values of the resultant voxel-based COVs were 6.2%, 7.2%, and 9.7% for N-acetylaspartate, creatine, and choline respectively. The corresponding mean values obtained following averaging over lobar-scale brain regions within the cerebrum were 3.5%, 3.7%, and 5.2%. These results indicate that longitudinal volumetric MRSI studies with post-acquisition registration can provide an intra-subject reproducibility for voxel-based analyses that is comparable to previously-reported single-voxel MRS measurements, while additionally enabling increased sensitivity by averaging over larger tissue volumes. |
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Authors:
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A A Maudsley; C Domenig; S Sheriff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: NMR in biomedicine Volume: 23 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-07-27 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 251-6 Citation Subset: IM |
Copyright Information:
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2009 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Radiology, University of Miami School of Medicine, Miami, FL 33136, USA. AMaudsley@med.miami.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives, metabolism Brain / metabolism* Brain Mapping / methods* Female Humans Magnetic Resonance Imaging / methods* Magnetic Resonance Spectroscopy Male Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB000822-07/EB/NIBIB NIH HHS; R01EB0822/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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