Document Detail

Reproducibility of serial intravascular ultrasound measurements in patients with angiographically silent coronary artery disease after heart transplantation.
MedLine Citation:
PMID:  11023244     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intracoronary ultrasound (ICUS) imaging is the most sensitive method for the early detection and serial evaluation of vasculopathy of transplants. Both lack of agreement between observers and lack of agreement between serial, independent pullback procedures (repeatability), which can result in a variable intraluminal catheter position may limit the reproducibility of ICUS measurements. OBJECTIVE: To evaluate the reproducibility of serial measurements of standard linear and area cross-sectional coronary dimensions in patients with non-obstructive transplant vasculopathy. METHODS: We performed ICUS imaging of patients without angiographic evidence of obstructive epicardial coronary artery disease after heart transplantation. A 30 MHz phased-array transducer was used. Two independent pullbacks of the left anterior descending coronary artery were performed and recorded on CD-ROM for off-line quantitative analysis of the most severely diseased site. Agreement of observers and repeatability of serial measurements were calculated by the use of linear regression analysis and Bland-Altman plots. RESULTS: Regarding agreement of observers, correlation coefficients for intra-observer agreement ranged from r = 0.98 to r = 0.99; those for interobserver agreement ranged from r = 0.87 to r = 0.98. Serial measurements of the identical coronary artery cross-section within independent catheter pullback procedures were possible for 104 of 112 target lesions (92.90/%). Correlation coefficients ranged from r = 0.91 to r = 0.97 (for lumen diameter r = 0.91, for lumen area r = 0.93, for vessel diameter r = 0.91, for vessel area r = 0.97, for thickness of plaque r = 0.96 and for area of plaque 0.94). The mean difference of measurements was around zero for all parameters with SD from 0.13 to 0.4 mm for linear parameters and from 1.53 to 1.82 mm2 for area parameters. CONCLUSION: Serial intravascular ultrasound measurements are highly reproducible without any evidence of systematic error and a SD of differences of measurements beyond the maximal spatial resolution of currently available intravascular ultrasound catheters.
W Bocksch; E Wellnhofer; M Schartl; S Dreysse; W Klimek; R Franke; M Musci; R Hetzer; E Fleck
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  11     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-62     Citation Subset:  IM    
Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Humboldt Universität zu Berlin.
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MeSH Terms
Coronary Angiography
Coronary Artery Disease / pathology,  ultrasonography
Coronary Disease / pathology*,  radiography,  ultrasonography
Coronary Vessels / pathology*,  ultrasonography*
Heart Transplantation*
Middle Aged
Observer Variation
Prospective Studies
Regression Analysis
Reproducibility of Results
Ultrasonography, Interventional* / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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