| Reproducibility of reference tissue quantification of dynamic contrast-enhanced data: comparison with a fixed vascular input function. | |
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MedLine Citation:
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PMID: 17183129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reference tissues are currently used to analyse dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data. The assessment of tumour response to treatment with anti-cancer drugs is a particularly important application of this type of analysis and requires a measure of reproducibility to define a level above which a significant change due to therapy can be inferred. This study compares the reproducibility of such quantification strategies with that found using a published, group-averaged uptake curve. It is shown that reference tissue quantification gives poorer reproducibility for most parameters than that found using a group-averaged plasma curve (a change in K(trans) of greater than 41.8% and 16.4% would be considered significant in the two approaches, respectively), but successfully incorporates some of the variability observed in plasma kinetics between visits and provides vascular input functions that, across the group, are comparable with the group-averaged curve. This study therefore provides an indirect validation of the methodology. |
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Authors:
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S Walker-Samuel; C C Parker; M O Leach; D J Collins |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-06 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 52 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-21 Completed Date: 2007-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 75-89 Citation Subset: IM |
Affiliation:
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Cancer Research UK Clinical Magnetic Resonance Imaging Research Group, Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT, UK. simon.walker@icr.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology Cohort Studies Contrast Media / pharmacology Female Humans Image Processing, Computer-Assisted / methods Kinetics Magnetic Resonance Imaging / methods* Male Models, Statistical Monte Carlo Method Muscles / pathology Protons Reference Standards Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Contrast Media; 0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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