Document Detail

Reproducibility of long-term ambulatory esophageal combined pH/manometry.
MedLine Citation:
PMID:  2019368     Owner:  NLM     Status:  MEDLINE    
Long-term ambulatory esophageal manometry is used increasingly, but normal values and data on the reproducibility of the method are not available. Thus, studies were conducted using paired 24-hour recordings, separated by 1-4 weeks, in 24 healthy volunteers (aged 19-50). Computerized analysis of each two-channel pressure recording (5 and 15 cm above lower esophageal sphincter) determined mean contraction amplitude, duration, area under the curve, contractility and propagation velocity, and the proportion of propagated contractions during day and night periods. A combined glass pH electrode (5 cm above lower esophageal sphincter) was used to register acid reflux. Visual analysis of the 24-hour contractility patterns showed marked intraindividual reproducibility but, although most subjects showed similar meal-associated increases and sleep-associated decreases in contraction frequency and amplitude, considerable interindividual variation was observed. This was confirmed by comparing the variation between subjects in the first and second recordings with the variation between recordings in the same subject; for all pH and manometry variables, the coefficient of variation was two to three times greater between subjects than between recordings in the same subject. The recordings were highly reproducible within subjects (nighttime contraction duration, P less than 0.05; all other variables, P less than 0.01). Thus, computerized ambulatory pH manometry is reproducible and because healthy volunteers have a characteristic individual pattern of esophageal motility, the method is perfectly suitable for repeated-measure design physiological and pharmacological studies. However, generally applicable normal values are difficult to define.
C Emde; D Armstrong; F Castiglione; T Cilluffo; E O Riecken; A L Blum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  100     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-05-30     Completed Date:  1991-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1630-7     Citation Subset:  AIM; IM    
Division de gastro-entérologie, Centre Hospitalier Universitaire Vaudois (CHUV/PMU), Lausanne, Switzerland.
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MeSH Terms
Esophagogastric Junction / physiology
Esophagus / physiology*
Hydrogen-Ion Concentration
Monitoring, Physiologic / methods*
Muscle, Smooth / physiology
Peristalsis / physiology
Reference Values
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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