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Reproducibility of left and right ventricular mass measurements with cardiac CT.
MedLine Citation:
PMID:  21875827     Owner:  NLM     Status:  Publisher    
BACKGROUND: Cardiac CT provides volumetric data that enables characterization of the myocardium. OBJECTIVE: We evaluated intraobserver, interobserver, and interstudy reproducibility of left ventricular (LV) and right ventricular (RV) mass quantification with cardiac CT. METHODS: Thirty-eight patients who underwent cardiac CT twice within 365 days were included in this analysis. Functional reconstructions in 10% steps throughout the R-R interval and axial 1.5-mm sections were used. Semiautomatic contour detection was used to trace epicardial and endocardial borders in all cardiac phases for calculation of LV and RV ejection fraction, end-diastolic volume, end-systolic volume, cardiac output, stroke volume, and ventricular mass. For each study 2 observers measured LV and RV mass twice. RESULTS: LV mass parameters derived from semiautomatic contour detection algorithm had excellent intraobserver (r = 1.00), interobserver (r = 0.99), and interstudy (r = 0.99) reproducibility (P < 0.0001). Average end-diastolic LV mass was 146.2 ± 42.9 g at the first CT study and 146.8 ± 44.4 g at the second study. For measuring RV mass, reproducibility was good on all levels (r = 0.78, r = 0.78, and r = 0.68, respectively, with an average end-diastolic mass of 25.7 ± 5.8 g at the first study and 24.4 ± 4.8 g at the second study. CONCLUSION: Quantification of LV mass at cardiac CT with the threshold-based, region-growing semiautomatic segmentation analysis software evaluated here is highly observer independent and reproducible. This largely holds true for the estimation of RV mass as well; however, further improvements are needed to optimize reproducibility for RV mass quantification.
Florian Schwarz; Richard Takx; U Joseph Schoepf; Yeong Shyan Lee; Balazs Ruzsics; Eva Maria Gassner; Salvatore Chiaramida; Thomas Henzler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-7
Journal Detail:
Title:  Journal of cardiovascular computed tomography     Volume:  -     ISSN:  1876-861X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308347     Medline TA:  J Cardiovasc Comput Tomogr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
Heart and Vascular Center, Medical University of South Carolina, 25 Courtenay Dr, Charleston, SC 29401, USA; Institute of Clinical Radiology, Ludwig-Maximilians University, Campus Grosshadern, Munich, Germany.
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