| Reproducibility of flow and wall shear stress analysis using flow-sensitive four-dimensional MRI. | |
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MedLine Citation:
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PMID: 21448968 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To systematically investigate the scan-rescan reproducibility and observer variability of flow-sensitive four-dimensional (4D) MRI in the aorta for the assessment of blood flow and global and segmental wall shear stress. MATERIALS AND METHODS: ECG and respiration-synchronized flow-sensitive 4D MRI data (spatio-temporal resolution = 1.7 × 2.0 × 2.2 mm(3) /40.8 ms) were acquired in 12 healthy volunteers. To analyze scan-rescan variability, flow-sensitive 4D MRI was repeated in 10 volunteers during a second visit. Data analysis included calculation of time-resolved and total flow, peak systolic velocity, and regional and global wall shear stress (WSS) in up to 24 analysis planes distributed along the aorta. RESULTS: Scan-rescan, inter-observer, and intra-observer agreement was excellent for the calculation of total flow and peak systolic velocity (mean differences <5% of the average flow parameter). Global WSS demonstrated moderate agreement and increased variability regarding wall shear stress (scan-rescan, inter-observer, and intra-observer agreement; mean differences <10% of the average WSS parameters). The segmental distribution of wall shear stress in the thoracic aorta could reliably be reproduced (r > 0.87; P < 0.001) for different observers and examinations. CONCLUSION: Flow-sensitive 4D MRI-based analysis of aortic blood flow can be performed with good reproducibility. Robustness of global and regional WSS quantification was limited, but spatio-temporal WSS distributions could reliably be replicated. J. Magn. Reson. Imaging 2011;33:988-994. © 2011 Wiley-Liss, Inc. |
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Authors:
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Michael Markl; Wolf Wallis; Andreas Harloff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 988-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology - Medical Physics, University Hospital Freiburg, Germany. michael.markl@uniklinik-freiburg.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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