Document Detail

Reproducibility of double indicator dilution measurements of intrathoracic blood volume compartments, extravascular lung water, and liver function.
MedLine Citation:
PMID:  9554649     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: Arterial thermal dye dilution (TDDart) with the COLD system (Munich, Germany) allows measurement of cardiac index (CI), partial blood volumes, lung water, and liver function. The aim of the study was to determine agreement of TDDart measurements with pulmonary artery thermal dilution measurements (TDpa) and to assess the reproducibility of TDDart parameters. DESIGN: Prospective study. SETTING: ICU of a university hospital department of cardiac surgery. PATIENTS: Thirty consecutive patients after coronary artery bypass grafting. MEASUREMENTS AND RESULTS: Triplicate measurements of TDDart parameters were performed 1, 3, 6, 12, and 24 h postoperatively and coefficients of variation (CVs) were computed. At the 3-h point, additional fivefold TDDart measurements were done and compared with TDpa measurements. The coefficient of correlation for CI from TDDart vs TDpa was 0.96 (p<0.001), and the mean difference was 0.16 L/min/m2 (2.4%). The CVs of the TDDart and TDpa CI measurement were 7.2% and 5.9%; the CVs of other TDDart parameters were 4.6% (cardiac function index), 8.3% (global end-diastolic volume), 7.0% (intrathoracic blood volume), 7.6% (total blood volume), 7.4% (right ventricular end-diastolic volume), 7.4% (right heart end-diastolic volume), 11.3% (left heart end-diastolic volume [LHEDV]), 12.0% (right to left heart volume proportion [R/LHV]), 8.8% (pulmonary blood volume), 10.8% (extravascular lung water), 16.4% (plasma disappearance rate of dye), and 19.8% (dye clearance). The CV did not depend on Glasgow coma scale or on body temperature. CONCLUSION: The CVs of LHEDV and R/LHV are influenced by asynchronous TDDart and TDpa variation. The CVs of plasma disappearance and dye clearance are increased as the half-life of the dye is longer than the measurement sequence. All other parameters derived from TDDart and TDpa show a clinically sufficient reproducibility.
O Godje; M Peyerl; T Seebauer; O Dewald; B Reichart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  113     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-04     Completed Date:  1998-05-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1070-7     Citation Subset:  AIM; IM    
Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany.
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MeSH Terms
Aged, 80 and over
Blood Volume Determination / methods*
Coloring Agents / diagnostic use
Coronary Disease / physiopathology*
Dye Dilution Technique
Extravascular Lung Water*
Indicator Dilution Techniques*
Indocyanine Green / diagnostic use
Liver Function Tests
Middle Aged
Prospective Studies
Reproducibility of Results
Reg. No./Substance:
0/Coloring Agents; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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