Document Detail

Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging.
MedLine Citation:
PMID:  16631003     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to evaluate the reproducibility of acute and chronic infarct size (IS) by delayed enhancement (DE) magnetic resonance imaging (MRI). BACKGROUND: Infarct size measurements can be used as surrogate end point to reduce the sample size in studies comparing different reperfusion strategies in myocardial infarction (MI). Delayed enhancement MRI is a rather new technique, and so far infarct IS reproducibility has not been established appropriately. METHODS: In 21 patients (10 acute MI and 11 chronic MI), IS was assessed repeatedly on consecutive days by DE-MRI. Reproducibility, interobserver, and intraobserver variabilities were assessed and compared by the Bland-Altman method. RESULTS: Acute and chronic IS were 17.1 +/- 19.6% (range 5.1% to 69.8%) of LV mass (%LV) and 16.9 +/- 9.9 %LV (range 2.0% to 36.0%), respectively. Infarct size difference (bias) between scan I and scan II was -0.5 %LV, and limits of agreement were +/-2.4 %LV. Mean bias (-0.7 %LV) and limits of agreement (+/-3.2%) were slightly higher for acute in comparison with chronic MI with -0.4 +/- 1.3 %LV. Intraobserver and interobserver variability was low with a mean bias of 0.3 %LV (limits of agreement +/- 1.7 %LV) and -0.7 %LV (limits of agreement +/- 2.2 %LV), respectively. CONCLUSIONS: Infarct size measurement by DE-MRI is an excellent tool for IS assessment, owing to its excellent repeatability in chronic and acute MI. It has therefore the potential to serve as a surrogate end point to uncover advantages of new reperfusion strategies.
Holger Thiele; Mathias J E Kappl; Stefan Conradi; Josef Niebauer; Rainer Hambrecht; Gerhard Schuler
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Publication Detail:
Type:  Journal Article     Date:  2006-03-27
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  47     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1641-5     Citation Subset:  AIM; IM    
Department of Cardiology, University of Leipzig-Heart Center, Leipzig, Germany.
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MeSH Terms
Acute Disease
Aged, 80 and over
Chronic Disease
Image Enhancement*
Magnetic Resonance Imaging*
Middle Aged
Myocardial Infarction / diagnosis*
Observer Variation
Reproducibility of Results
Time Factors
Comment In:
J Am Coll Cardiol. 2006 Apr 18;47(8):1646-8   [PMID:  16631004 ]

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