Document Detail

Reproducibility of cardiopulmonary effects of different endotoxins in the same sheep.
MedLine Citation:
PMID:  6343317     Owner:  NLM     Status:  MEDLINE    
This study compares qualitative and quantitative differences between the cardiopulmonary responses to Salmonella typhimurium and Escherichia coli 055:B5 endotoxins (Difco) in the same sheep model. Lipopolysaccharides, 0.75 micrograms/kg, were infused into chronically instrumented sheep over 30 min. Cardiopulmonary and pulmonary lymph flux data were collected for 2 h prior to and 6 h following this. One week later the sequence was repeated with another endotoxin. The administration of the two endotoxins was varied: some received S. typhimurium first; others received E. coli. A total of 13 animals were studied; 8 had intact pulmonary lymphatic catheters. Following each injection of endotoxin these animals showed a typical response of early high pressure-mediated increase in pulmonary lymph flow and later lymph flow elevation associated with a very mild increase in microvascular pressure and lymph with normal protein levels. These changes were associated with hemoconcentration, lowered arterial oxygen partial pressure, cardiac index, and blood neutrophil count. It is concluded that Difco S. typhimurium and E. coli endotoxins are similar in their mechanism of action and potency and can be studied in the same animal.
D L Traber; T Adams; N Henriksen; L D Traber; P D Thomson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  54     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1167-71     Citation Subset:  IM    
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MeSH Terms
Endotoxins / pharmacology*
Escherichia coli*
Heart / drug effects*
Leukocyte Count
Lung / drug effects*,  metabolism
Lymph / metabolism
Salmonella typhimurium*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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