| Reproducibility of blood pressure response to hydrochlorothiazide. | |
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MedLine Citation:
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PMID: 12461303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few studies have investigated the reproducibility of responses to antihypertensive therapies. The purpose of this study was to assess the reproducibility of the blood pressure response to a thiazide diuretic, a preferred initial treatment for hypertension. Twenty-two subjects who underwent monotherapy with hydrochlorothiazide as part of a study to identify predictors of blood pressure response agreed to undergo the same protocol a second time, 26.6+/-11.8 (range, 4-52) months after their first participation. The mean systolic and diastolic blood pressure responses to hydrochlorothiazide did not differ significantly between the first and second participation (systolic response, -14.2+/-16.4 mm Hg vs. -16.0+/-16.5 mm Hg; diastolic response, -7.1+/-11.8 mm Hg vs. -6.6+/-8.6 mm Hg), and these responses were significantly correlated between the two trials (systolic response, r=0.61 and p<0.01; diastolic response, r=0.64 and p<0.01). However, both the direction and magnitude of responses for individual subjects varied considerably, with the limits of agreement between the first and second participations (i.e., 2 standard deviations above and below the mean difference between responses) ranging from 27.4 mm Hg to -23.8 mm Hg for systolic blood pressure response and from 17.4 mm Hg to -18.4 mm Hg for diastolic blood pressure response. These results show that the average systolic and diastolic blood pressure responses to hydrochlorothiazide for a group of subjects are reproducible; however, the responses for individual subjects are unpredictable. |
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Authors:
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Javier D Finkielman; Gary L Schwartz; Arlene B Chapman; Eric Boerwinkle; Stephen T Turner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 4 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-12-03 Completed Date: 2003-04-03 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 408-12 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Le Jacq Communications, Inc. |
Affiliation:
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Division of Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Americans
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statistics & numerical data Antihypertensive Agents / therapeutic use* Diuretics Female Hispanic Americans / statistics & numerical data Humans Hydrochlorothiazide / therapeutic use* Hypertension / drug therapy* Male Middle Aged Reproducibility of Results Sodium Chloride Symporter Inhibitors / therapeutic use* Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Diuretics; 0/Sodium Chloride Symporter Inhibitors; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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