| Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbits. | |
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MedLine Citation:
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PMID: 20578026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the short-term reproducibility of black-blood dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in atherosclerotic rabbits to evaluate the potential of this technique to be a reliable readout of plaque progression and/or regression upon therapeutic intervention. MATERIALS AND METHODS: Atherosclerotic rabbits were imaged at baseline and 24 hours later with DCE-MRI on a 1.5T MRI system. DCE-MRI images were analyzed by calculating the area under the signal intensity versus time curve (AUC). Intraclass correlation coefficients (ICCs) were used to evaluate interscan, intraobserver, and interobserver reproducibility. In addition, the test-retest coefficient of variation (CoV) was evaluated. RESULTS: Statistical analyses showed excellent interscan, intraobserver, and interobserver agreement. All ICCs were greater than 0.75, P < 0.01 indicating excellent agreement between measurements. CONCLUSION: Experimental results show good interscan and excellent intra- and interobserver reproducibility, suggesting that DCE-MRI could be used in preclinical settings as a read-out for novel therapeutic interventions for atherosclerosis. This preliminary work encourages investigating the reproducibility of DCE-MRI also in clinical settings, where it could be used for monitoring high-risk patients and in longitudinal clinical drug trials. |
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Authors:
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Claudia Calcagno; Esad Vucic; Venkatesh Mani; Gregg Goldschlager; Zahi A Fayad |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 191-8 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Translational and Molecular Imaging Institute, Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology* Aorta, Abdominal / pathology Area Under Curve Atherosclerosis / pathology* Contrast Media / diagnostic use* Disease Models, Animal Gadolinium DTPA / diagnostic use* Image Enhancement / methods* Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging / methods* Male Observer Variation Rabbits Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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HL71021/HL/NHLBI NIH HHS; R01 EB 009638/EB/NIBIB NIH HHS; R01 HL 78667/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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