Document Detail


Reproducibility of atopy patch tests with food and inhalant allergens.
MedLine Citation:
PMID:  18394315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although atopy patch tests (APT) seem a valuable additional tool in the diagnostic work-up for food allergy in children with atopic eczema/dermatitis syndrome, the immunopathology and some technical aspects of testing remain controversial. Few published data are available on the reproducibility of APT with inhalants and only two studies include fresh food allergens. In this study we therefore investigated the reproducibility of duplicate APT (left versus right side of the back) with native and commercially available food (cow s milk, hen s egg, tomato, wheat flour) and with inhalant allergens (Dermatophagoides pteronyssinus and mixed grasses) in a large unselected population of children. We tested a population of 277 Italian school children with three APT allergens: fresh food (cow s milk, hen s egg, tomato and wheat flour), standardised food allergens in petrolatum (the same four foods) and standardised inhalant allergens routinely used for skin prick testing. For the four food allergens (applied in the natural form or as the standardised commercial preparation) from one- to three quarters of the APT gave positive results on one side and negative reactions on the opposite side (Cohen s K coefficient between 0.38, fresh tomato and 0.81, fresh cow s milk). Conversely, APT with inhalant allergens were invariably reproducible (Cohen s K = 1.00). The possible technical and immunologic reasons explaining why reproducibility of APT differed for the two types of allergens await an answer from extensive controlled studies.
Authors:
R Ronchetti; M Jesenak; S Barberi; F Ronchetti; Z Rennerova; D Trubacova; M P Villa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  22     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    2008 Jan-Mar
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Second School of Medicine, University Sapienza, Rome, Italy. roberto.ronchetti@ospedalesantandrea.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Allergens / administration & dosage,  adverse effects*
Child
Female
Food Hypersensitivity*
Humans
Hypersensitivity, Immediate / chemically induced*
Male
Patch Tests / methods*
Reproducibility of Results
Rome
Chemical
Reg. No./Substance:
0/Allergens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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