| Reproducibility assessment of metabolic variables characterizing muscle energetics in vivo: A 31P-MRS study. | |
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MedLine Citation:
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PMID: 19725136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to assess the reliability of metabolic parameters measured using (31)P magnetic resonance spectroscopy ((31)P MRS) during two standardized rest-exercise-recovery protocols. Twelve healthy subjects performed the standardized protocols at two different intensities; i.e., a moderate intensity (MOD) repeated over a two-month period and heavy intensity (HEAVY) repeated over a year's time. Test-retest reliability was analyzed using coefficient of variation (CV), limits of agreement (LOA), and intraclass correlation coefficients (ICC). During exercise and recovery periods, most of the metabolic parameters exhibited a good reliability. The CVs of individual concentration of phosphocreatine ([PCr]), concentration of adenosine diphosphate ([ADP]), and pH values recorded at end of the HEAVY exercise were lower than 15%. The CV calculated for the rate of PCr resynthesis and the maximal oxidative capacity were less than 13% during the HEAVY protocol. Inferred parameters such as oxidative and total adenosine triphosphate (ATP) production rates exhibited a good reliability (ICC approximately 0.7; CV < 15% during the HEAVY protocol). Our results demonstrated that measurement error using (31)P-MRS during a standardized exercise was low and that biological variability accounted for the vast majority of the measurement variability. In addition, the corresponding metabolic measurements can reliably be used for longitudinal studies performed even over a long period of time. |
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Authors:
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Gwenael Layec; Aur??lien Bringard; Yann Le Fur; Christophe Vilmen; Jean-Paul Micallef; St??phane Perrey; Patrick J Cozzone; David Bendahan |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 62 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 840-54 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Facult?? de M??decine de Marseille, Marseille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Energy Metabolism / physiology* Female Humans Magnetic Resonance Spectroscopy / methods* Male Muscle, Skeletal / physiology* Phosphocreatine / analysis, metabolism* Phosphorus Isotopes / metabolism Physical Exertion / physiology* Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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