| Reproducibility of the ambulatory arterial stiffness index in hypertensive patients. | |
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MedLine Citation:
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PMID: 18806623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We studied the repeatability of the ambulatory arterial stiffness index (AASI), which can be computed from 24-h blood pressure (BP) recordings as unity minus the regression slope of diastolic on systolic BP. METHODS: One hundred and fifty-two hypertensive outpatients recruited in Nijmegen (mean age = 46.2 years; 76.3% with systolic and diastolic hypertension) and 145 patients enrolled in the Systolic Hypertension in Europe (Syst-Eur) trial (71.0 years) underwent 24-h BP monitoring at a median interval of 8 and 31 days, respectively. We used the repeatability coefficient, which is twice the SD of the within-participant differences between repeat recordings, and expressed it as a percentage of four times the SD of the mean of the paired measurements. RESULTS: Mean AASI (crude or derived by time-weighted or robust regression) and 24-h pulse pressure (PP) were similar on repeat recordings in both cohorts. In Nijmegen patients, repeatability coefficients of AASI and PP were approximately 50%. In Syst-Eur trial patients, repeatability coefficient was approximately 60% for AASI and approximately 40% for PP. For comparison, repeatability coefficients for 24-h systolic and diastolic BP were approximately 30%. Differences in AASI between paired recordings were correlated with differences in the goodness of fit (r2) of the AASI regression line as well as with differences in the night-to-day BP ratio. However, in sensitivity analyses stratified for type of hypertension, r2, or dipping status, repeatability coefficients for AASI did not widely depart from 50 to 60% range. CONCLUSION: Estimates of mean AASI were not different between repeat recordings, and repeatability coefficients were within the 50-60% range. |
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Authors:
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Dirk G Dechering; Marijke S van der Steen; Ahmet Adiyaman; Lutgarde Thijs; Jaap Deinum; Yan Li; Eamon Dolan; Reinier Pm Akkermans; Tom Richart; Tine W Hansen; Masahiro Kikuya; Jiguang Wang; Eoin O'brien; Theo Thien; Jan A Staessen |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Journal of hypertension Volume: 26 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-12-09 Revised Date: 2009-04-07 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1993-2000 Citation Subset: IM |
Affiliation:
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Department of General Internal Medicine, University Medical Centre St Radboud, Radboud University, Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteries / physiopathology* Blood Pressure Blood Pressure Monitoring, Ambulatory* Female Humans Hypertension / physiopathology* Male Middle Aged Predictive Value of Tests |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2009 Feb;27(2):435-6; author reply 436-7
[PMID:
19155797
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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