Document Detail


Reproducibility of the ambulatory arterial stiffness index in hypertensive patients.
MedLine Citation:
PMID:  18806623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We studied the repeatability of the ambulatory arterial stiffness index (AASI), which can be computed from 24-h blood pressure (BP) recordings as unity minus the regression slope of diastolic on systolic BP. METHODS: One hundred and fifty-two hypertensive outpatients recruited in Nijmegen (mean age = 46.2 years; 76.3% with systolic and diastolic hypertension) and 145 patients enrolled in the Systolic Hypertension in Europe (Syst-Eur) trial (71.0 years) underwent 24-h BP monitoring at a median interval of 8 and 31 days, respectively. We used the repeatability coefficient, which is twice the SD of the within-participant differences between repeat recordings, and expressed it as a percentage of four times the SD of the mean of the paired measurements. RESULTS: Mean AASI (crude or derived by time-weighted or robust regression) and 24-h pulse pressure (PP) were similar on repeat recordings in both cohorts. In Nijmegen patients, repeatability coefficients of AASI and PP were approximately 50%. In Syst-Eur trial patients, repeatability coefficient was approximately 60% for AASI and approximately 40% for PP. For comparison, repeatability coefficients for 24-h systolic and diastolic BP were approximately 30%. Differences in AASI between paired recordings were correlated with differences in the goodness of fit (r2) of the AASI regression line as well as with differences in the night-to-day BP ratio. However, in sensitivity analyses stratified for type of hypertension, r2, or dipping status, repeatability coefficients for AASI did not widely depart from 50 to 60% range. CONCLUSION: Estimates of mean AASI were not different between repeat recordings, and repeatability coefficients were within the 50-60% range.
Authors:
Dirk G Dechering; Marijke S van der Steen; Ahmet Adiyaman; Lutgarde Thijs; Jaap Deinum; Yan Li; Eamon Dolan; Reinier Pm Akkermans; Tom Richart; Tine W Hansen; Masahiro Kikuya; Jiguang Wang; Eoin O'brien; Theo Thien; Jan A Staessen
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Journal of hypertension     Volume:  26     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-12-09     Revised Date:  2009-04-07    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1993-2000     Citation Subset:  IM    
Affiliation:
Department of General Internal Medicine, University Medical Centre St Radboud, Radboud University, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arteries / physiopathology*
Blood Pressure
Blood Pressure Monitoring, Ambulatory*
Female
Humans
Hypertension / physiopathology*
Male
Middle Aged
Predictive Value of Tests
Comments/Corrections
Comment In:
J Hypertens. 2009 Feb;27(2):435-6; author reply 436-7   [PMID:  19155797 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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