Document Detail

Reproducibility of T2* blood volume and vascular tortuosity maps in cerebral gliomas.
MedLine Citation:
PMID:  11747002     Owner:  NLM     Status:  MEDLINE    
The development of anti-angiogenic therapies for tumors has led to a demand for imaging-based surrogate markers of the angiogenic process. The utility of such markers is highly dependent on their test-retest reproducibility. This paper presents a formal assessment of the reproducibility of measurements of relative blood volume (rBV), normalized rBV (rBVnorm), and vascular tortuosity as estimated by measurement of relative recirculation (rR). The study was conducted in 11 patients with glioma who were scanned on two occasions 36-56 hours apart. The observed reliability estimates were used to calculate 95% confidence limits for detection of differences between groups and for changes in individual cases. The results show that measurement of rBV or rBVnorm in consecutive studies is statistically capable of reliably detecting changes in excess of 15% in between group studies and 25% in individual patients. Measurement of vascular tortuosity using is less reproducible but is able to confidently identify changes in excess of 30% in group studies and 35% in individuals.
A Jackson; A Kassner; X P Zhu; K L Li
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  14     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-01-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-6     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Imaging Science and Biomedical Engineering, University of Manchester, UK.
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MeSH Terms
Blood Volume
Brain / pathology*
Brain Neoplasms / blood supply*,  pathology
Cerebrovascular Circulation
Contrast Media
Gadolinium DTPA / diagnostic use
Glioma / blood supply*,  pathology
Magnetic Resonance Imaging / methods*
Reproducibility of Results
Reg. No./Substance:
0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA

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