Document Detail

Reproducibility of IVUS border detection for carotid atherosclerotic plaque assessment.
MedLine Citation:
PMID:  21981807     Owner:  NLM     Status:  MEDLINE    
Plaque composition is a potentially important diagnostic feature for carotid artery stenting (CAS). The purpose of this investigation is to evaluate the reproducibility of manual border correction in intravascular ultrasound with virtual histology (VH IVUS) images. Three images each were obtained from 51 CAS datasets on which automatic border detection was corrected manually by two trained observers. Plaque was classified using the definitions from the CAPITAL (Carotid Artery Plaque Virtual Histology Evaluation) study, listed in order from least to most pathological: no plaque, pathological intimal thickening, fibroatheroma, fibrocalcific, calcified fibroatheroma, thin-cap fibroatheroma, and calcified thin-cap fibroatheroma. Inter-observer variability was quantified using both weighted and unweighted Kappa statistics. Bland-Altman analysis was used to compare the cross-sectional areas of the vessel and lumen. Agreement using necrotic core percentage as the criterion was evaluated using the unweighted Kappa statistic. Agreement between classifications of plaque type was evaluated using the weighted Kappa statistic. There was substantial agreement between the observers based on necrotic core percentage (κ=0.63), while the agreement was moderate (κ(quadratic)=0.60) based on plaque classification. Due to the time-consuming nature of manual border detection, an improved automatic border detection algorithm is necessary for using VH IVUS as a diagnostic tool for assessing the suitability of patients with carotid artery occlusive disease for CAS.
Gail M Siewiorek; Natasha A Loghmanpour; Brion M Winston; Mark H Wholey; Ender A Finol
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-06
Journal Detail:
Title:  Medical engineering & physics     Volume:  34     ISSN:  1873-4030     ISO Abbreviation:  Med Eng Phys     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-06     Completed Date:  2012-11-16     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  England    
Other Details:
Languages:  eng     Pagination:  702-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 IPEM. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Aged, 80 and over
Carotid Arteries / pathology*,  ultrasonography*
Carotid Artery Diseases / pathology*,  ultrasonography*
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Observer Variation
Plaque, Atherosclerotic / pathology*,  ultrasonography*
Reproducibility of Results
Grant Support
T32 EB003391-01/EB/NIBIB NIH HHS; T32 EB003392/EB/NIBIB NIH HHS; T32 EB003392-01A1/EB/NIBIB NIH HHS

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