Document Detail


Reproducibility of blood pressure response to the cold pressor test: the GenSalt Study.
MedLine Citation:
PMID:  23035148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An elevated blood pressure (BP) response to the cold pressor test (CPT) is associated with increased risk of hypertension and cardiovascular disease. However, it is still unclear whether BP response to the CPT is a stable and reproducible trait over time. Using the same study protocol, the authors repeated the CPT 4.5 years after initial administration among 568 Han Chinese in rural northern China (2003-2005 and 2008-2009). BP was measured using a standard mercury sphygmomanometer prior to and 0, 1, 2, and 4 minutes after the participants immersed their hand in ice water (3°C-5°C) for 1 minute. Absolute BP levels and BP responses during the CPT in the initial and repeated administrations were highly correlated. For example, the correlation coefficients were 0.67, 0.73, 0.71, and 0.72 for absolute systolic BP levels at 0, 1, 2, and 4 minutes after ice-water immersion (all P 's < 0.0001). The correlation coefficients for systolic BP response were 0.41 at 0 minutes, 0.37 at 1 minute, 0.42 for maximum response, and 0.39 for the area under the curve during CPT (all P 's < 0.0001). These data indicate that BP response to the CPT is a long-term reproducible and stable characteristic in the general population.
Authors:
Qi Zhao; Lydia A Bazzano; Jie Cao; Jianxin Li; Jichun Chen; Jianfeng Huang; Jing Chen; Tanika N Kelly; Chung-Shiuan Chen; Dongsheng Hu; Jixiang Ma; Treva K Rice; Jiang He; Dongfeng Gu
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of epidemiology     Volume:  176 Suppl 7     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2012-12-17     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S91-8     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Pressure / physiology*
Blood Pressure Determination / methods
China
Cold Temperature / diagnostic use*
Female
Humans
Hypertension / diagnosis,  physiopathology
Male
Middle Aged
Reproducibility of Results
Young Adult
Grant Support
ID/Acronym/Agency:
R01HL087263/HL/NHLBI NIH HHS; R01HL090682/HL/NHLBI NIH HHS; U01HL072507/HL/NHLBI NIH HHS
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