Document Detail


Reproducibility of BOLD localization of interictal activity in patients with focal epilepsy: intrasession and intersession comparisons.
MedLine Citation:
PMID:  21710328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: Simultaneous EEG-fMRI recordings allow the identification of haemodynamic changes induced by neuronal activity during ictal or interictal epileptiform events (IEDs). We evaluated the reproducibility of continuous EEG-fMRI (cEEG-fMRI) in patients with focal epilepsy.
MATERIALS AND METHODS: We studied 15 patients with focal epilepsy (8 cryptogenic and 7 symptomatic) and frequent interictal abnormalities. Each patient underwent two cEEG-fMRI acquisitions (runs) in the same day (session) and 8 patients repeated the examination after one month. cEEG-fMRI reproducibility was defined by the existence of partially overlapping clusters between activation maps obtained from different runs.
RESULTS: We detected IEDs in 40 out of 46 EEG-fMRI runs and a related significant BOLD-response in all 40 runs. A prevalent positive BOLD response was detected in 12 patients and a prevalent negative response in 3 subjects. Statistical maps included a mean of 10 significant clusters. Nearly 30% of clusters were reproducible in both intrasession and intersession comparisons, with a mean overlap of 30%. Reproducibility did not differ between positive and negative BOLD-responses.
DISCUSSION: Among the reproducible clusters, those with the highest percentage of overlap were concordant with the EEG electric field in all patients and they were localized in the same lobe as the brain lesion in patients with symptomatic epilepsy. We hypothesize that reproducible clusters could be more consistently related to the irritative zone than non-reproducible ones.
CONCLUSION: The evaluation of cluster reproducibility could improve our knowledge of IED-related BOLD response. Moreover, it could enhance the reliability of cEEG-fMRI to identify the irritative zone in focal epileptic patients.
Authors:
Ilaria Pesaresi; Mirco Cosottini; Gina Belmonte; Patrizia Maritato; Mario Mascalchi; Michele Puglioli; Ferdinando Sartucci; Carlo Bartolozzi; Luigi Murri
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-06-28
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  24     ISSN:  1352-8661     ISO Abbreviation:  MAGMA     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-01-20     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  285-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiopathology
Brain Mapping / methods
Electroencephalography / methods*
Epilepsies, Partial / blood,  diagnosis*,  pathology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Oxygen / blood*,  metabolism*
Reproducibility of Results
Chemical
Reg. No./Substance:
S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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