| Reprint of: 'Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes' | |
| | |
MedLine Citation:
|
PMID: 22085799 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Understanding of the role of insulin in the brain has gradually expanded, from initial conceptions of the brain as insulin-insensitive through identification of a role in regulation of feeding, to recent demonstration of insulin as a key component of hippocampal memory processes. Conversely, systemic insulin resistance such as that seen in type 2 diabetes is associated with a range of cognitive and neural deficits. Here we review the evidence for insulin as a cognitive and neural modulator, including potential effector mechanisms, and examine the impact that type 2 diabetes has on these mechanisms in order to identify likely bases for the cognitive impairments seen in type 2 diabetic patients. |
| | |
Authors:
|
Ewan C McNay; Andrew K Recknagel |
Related Documents
:
|
22057379 - Electrophysiological studies in newly onset type 2 diabetes without visible vascular re... 6749629 - A radioreceptor assay for insulin: direct measurement of human serum insulin. 21191479 - Insulin modulation of magnetoencephalographic resting state dynamics in lean and obese ... 1086889 - Neuroelectric blocking factors in human and animal sera evaluated using the isolated fr... 6288789 - Development and loss of toluene diisocyanate reactivity: immunologic, pharmacologic, an... 3066649 - Normalization of complement activation and consumption in diabetic children and adolesc... 1659989 - Phenylarsine oxide stimulates a cytosolic tyrosine kinase activity and glucose transpor... 18158709 - Microalbuminuria and the metabolic syndrome in non-diabetic black africans. 7160539 - Autonomic neuropathy and the ventilatory responses of diabetics to progressive hypoxemi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-9 |
Journal Detail:
|
Title: Neurobiology of learning and memory Volume: - ISSN: 1095-9564 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Behavioral Neuroscience and Center for Neuroscience Research, University at Albany (SUNY), SS399, 1400 Washington Avenue, Albany, NY 12222, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-Term Femoral Bone Remodeling After Cemented Hip Arthroplasty With the Müller Straight Stem in ...
Next Document: Interacting brain systems modulate memory consolidation.