Document Detail

Repression of stromelysin metalloprotease expression in rat fibrosarcoma cells by dimethylsulfoxide.
MedLine Citation:
PMID:  8422709     Owner:  NLM     Status:  MEDLINE    
Metalloproteases are implicated in conferring invasive properties to tumor cells. We show here that treatment of ras-oncogene-transformed rat fibroblasts with dimethylsulfoxide (DMSO) results in a reversible decrease in stromelysin mRNA. Furthermore, stromelysin expression was found to be repressed by DMSO, but not by glucocorticoid hormone, in a fibrosarcoma cell line showing low AP-1 (fos/jun) transcription factor activity. In two fibrosarcoma cell lines which express high levels of stromelysin and low levels of 68 kDa type IV collagenase, the DMSO-induced decrease in stromelysin expression was paralleled by a decreased invasive propensity.
P Popowicz; G Engel; H Marshall; S Linder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & experimental metastasis     Volume:  11     ISSN:  0262-0898     ISO Abbreviation:  Clin. Exp. Metastasis     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-24     Completed Date:  1993-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409970     Medline TA:  Clin Exp Metastasis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Oncology, Radiumhemmet, Karolinska Institute and Hospital, Stockholm, Sweden.
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MeSH Terms
Blotting, Northern
Cell Adhesion / drug effects
Cell Division / drug effects
Cell Line, Transformed
Cell Movement / drug effects
Dimethyl Sulfoxide / pharmacology*
Enzyme Repression / drug effects
Fibrosarcoma / enzymology*,  pathology
Matrix Metalloproteinase 3
Metalloendopeptidases / biosynthesis,  drug effects*
Neoplasm Invasiveness / physiopathology
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
67-68-5/Dimethyl Sulfoxide; EC 3.4.24.-/Metalloendopeptidases; EC Metalloproteinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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