Document Detail

Repression of acyl-CoA:cholesterol acyltransferase by a traditional herbal medicine (Kampo medicine), Ogi-Keishi-Gomotsu-To-Ka-Kojin.
MedLine Citation:
PMID:  10513630     Owner:  NLM     Status:  MEDLINE    
Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK) is a traditional herbal medicine (Kampo medicine) which has been found to ameliorate hypercholesterolemia and hypertriglyceridemia in rats and rabbits. In the present study, the effect of OKGK on acyl-CoA:cholesterol acyltransferase (ACAT) was studied in order to elucidate the mechanism of its antihypercholesterolemic action. Oral administration of OKGK to rats fed a cholesterol-enriched diet for 4 weeks markedly repressed the increase in ACAT activity in the small intestine. In contrast, OKGK did not influence hepatic ACAT activity. These results indicate that OKGK selectively inhibits ACAT activity in the small intestine relative to that in the liver, resulting in a reduction of cholesterol absorption, followed by a decrease in serum cholesterol.
C Z Wu; M Inoue; Y Ogihara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  22     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  994-6     Citation Subset:  IM    
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Glands / drug effects
Drugs, Chinese Herbal / pharmacology*,  therapeutic use
Enzyme Repression
Hypercholesterolemia / drug therapy
Intestine, Small / drug effects*,  enzymology
Liver / drug effects*,  enzymology
Medicine, Kampo
Rats, Sprague-Dawley
Sterol O-Acyltransferase / antagonists & inhibitors*
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/ogi-keishi-gomotsu-to-ka-kojin; EC O-Acyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constitue...
Next Document:  The marked inhibition of the bitter taste of Polymyxin B sulfate and trimethoprim x sulfamethoxazole...