Document Detail


Repression of acyl-CoA:cholesterol acyltransferase by a traditional herbal medicine (Kampo medicine), Ogi-Keishi-Gomotsu-To-Ka-Kojin.
MedLine Citation:
PMID:  10513630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK) is a traditional herbal medicine (Kampo medicine) which has been found to ameliorate hypercholesterolemia and hypertriglyceridemia in rats and rabbits. In the present study, the effect of OKGK on acyl-CoA:cholesterol acyltransferase (ACAT) was studied in order to elucidate the mechanism of its antihypercholesterolemic action. Oral administration of OKGK to rats fed a cholesterol-enriched diet for 4 weeks markedly repressed the increase in ACAT activity in the small intestine. In contrast, OKGK did not influence hepatic ACAT activity. These results indicate that OKGK selectively inhibits ACAT activity in the small intestine relative to that in the liver, resulting in a reduction of cholesterol absorption, followed by a decrease in serum cholesterol.
Authors:
C Z Wu; M Inoue; Y Ogihara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  22     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  994-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / drug effects
Animals
Drugs, Chinese Herbal / pharmacology*,  therapeutic use
Enzyme Repression
Hypercholesterolemia / drug therapy
Intestine, Small / drug effects*,  enzymology
Liver / drug effects*,  enzymology
Male
Medicine, Kampo
Phytotherapy
Rats
Rats, Sprague-Dawley
Sterol O-Acyltransferase / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/ogi-keishi-gomotsu-to-ka-kojin; EC 2.3.1.26/Sterol O-Acyltransferase

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