Document Detail


Representation of natural stimuli in the rodent main olfactory bulb.
MedLine Citation:
PMID:  16772174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural odorants are complex mixtures of diverse chemical compounds. Monomolecular odorants are represented in the main olfactory bulb by distinct spatial patterns of activated glomeruli. However, it remains unclear how individual compounds contribute to population representations of natural stimuli, which appear to be unexpectedly sparse. We combined gas chromatography and intrinsic signal imaging to visualize glomerular responses to natural stimuli and their fractionated components. While whole stimuli activated up to 20 visible glomeruli, each fractionated component activated only one or few glomeruli, and most glomeruli were activated by only one component. Thus, responses to complex mixtures reflected activation by multiple components, with each contributing only a small part of the overall representation. We conclude that the population response to a complex stimulus is largely the sum of the responses to its individual components, and activation of an individual glomerulus independently signals the presence of a specific component.
Authors:
Da Yu Lin; Stephen D Shea; Lawrence C Katz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  50     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-07-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-49     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute and Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA. dayulin@neuro.duke.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping / methods*
Chromatography, Gas / methods
Female
Foxes
Lynx
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Odors* / analysis
Olfactory Bulb / chemistry,  physiology*
Rats
Sensitivity and Specificity
Smell / physiology*
Grant Support
ID/Acronym/Agency:
DC005671/DC/NIDCD NIH HHS
Comments/Corrections
Comment In:
Neuron. 2006 Jun 15;50(6):816-8   [PMID:  16772164 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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