Document Detail

Reporting of adverse events in systematic reviews can be improved: survey results.
MedLine Citation:
PMID:  18411039     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess how information about adverse events is included in systematic reviews. STUDY DESIGN AND SETTING: We included all new Cochrane reviews published in the Cochrane Database of Systematic Reviews (CDSRs) and all new reviews (2003--2004) in the Database of Abstracts of Reviews of Effects (DAREs) in Issue 1 2005 of The Cochrane Library. RESULTS: More than half of Cochrane (44/78) and DARE (46/79) reviews assessed drug interventions. The rest assessed surgery (Cochrane [12]; DARE [10]), psychosocial, educational, or physiotherapy interventions (22; 23). Seventy-six percent (59/78) of Cochrane reviews mentioned adverse events as an outcome compared with 48% (38/79) of DARE reviews. Most reviews mentioning adverse events were of drug interventions (Cochrane [41/59]; DARE reviews [29/38]). Considering reviews that mentioned adverse events, 95% (56/59) of Cochrane reviews included only randomized trials and 73% (43/59) included an analysis of adverse events. For 10 Cochrane reviews, adverse events had not been reported by the included trials. In contrast, 58% (22/38) of DARE reviews mentioning adverse events included only randomized trials, the rest included both randomized and nonrandomized studies. CONCLUSIONS: Most Cochrane reviews of drug interventions considered adverse events. This was not the case for DARE reviews and for Cochrane reviews of nondrug interventions. This could be improved.
Sally Hopewell; Luke Wolfenden; Mike Clarke
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Publication Detail:
Type:  Journal Article     Date:  2008-04-14
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  61     ISSN:  0895-4356     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-12     Completed Date:  2008-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-602     Citation Subset:  IM    
UK Cochrane Centre, Oxford OX2 7LG, UK.
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MeSH Terms
Databases, Bibliographic
Evidence-Based Medicine / standards*
Outcome Assessment (Health Care) / methods,  standards
Pharmaceutical Preparations / adverse effects*
Randomized Controlled Trials as Topic
Research Design
Review Literature as Topic*
Terminology as Topic
Therapeutics / adverse effects*
Reg. No./Substance:
0/Pharmaceutical Preparations

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