| Reporting of adverse events in systematic reviews can be improved: survey results. | |
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MedLine Citation:
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PMID: 18411039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess how information about adverse events is included in systematic reviews. STUDY DESIGN AND SETTING: We included all new Cochrane reviews published in the Cochrane Database of Systematic Reviews (CDSRs) and all new reviews (2003--2004) in the Database of Abstracts of Reviews of Effects (DAREs) in Issue 1 2005 of The Cochrane Library. RESULTS: More than half of Cochrane (44/78) and DARE (46/79) reviews assessed drug interventions. The rest assessed surgery (Cochrane [12]; DARE [10]), psychosocial, educational, or physiotherapy interventions (22; 23). Seventy-six percent (59/78) of Cochrane reviews mentioned adverse events as an outcome compared with 48% (38/79) of DARE reviews. Most reviews mentioning adverse events were of drug interventions (Cochrane [41/59]; DARE reviews [29/38]). Considering reviews that mentioned adverse events, 95% (56/59) of Cochrane reviews included only randomized trials and 73% (43/59) included an analysis of adverse events. For 10 Cochrane reviews, adverse events had not been reported by the included trials. In contrast, 58% (22/38) of DARE reviews mentioning adverse events included only randomized trials, the rest included both randomized and nonrandomized studies. CONCLUSIONS: Most Cochrane reviews of drug interventions considered adverse events. This was not the case for DARE reviews and for Cochrane reviews of nondrug interventions. This could be improved. |
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Authors:
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Sally Hopewell; Luke Wolfenden; Mike Clarke |
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Publication Detail:
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Type: Journal Article Date: 2008-04-14 |
Journal Detail:
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Title: Journal of clinical epidemiology Volume: 61 ISSN: 0895-4356 ISO Abbreviation: J Clin Epidemiol Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-12 Completed Date: 2008-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801383 Medline TA: J Clin Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 597-602 Citation Subset: IM |
Affiliation:
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UK Cochrane Centre, Oxford OX2 7LG, UK. shopewell@cochrane.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Databases, Bibliographic Evidence-Based Medicine / standards* Humans Outcome Assessment (Health Care) / methods, standards Pharmaceutical Preparations / adverse effects* Randomized Controlled Trials as Topic Research Design Review Literature as Topic* Terminology as Topic Therapeutics / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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