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Reported side effects of intravenous midazolam sedation when used in paediatric dentistry: a review.
MedLine Citation:
PMID:  25131504     Owner:  NLM     Status:  Publisher    
BACKGROUND: Intravenous (IV) midazolam may be of value as an alternative paediatric dental sedation technique, but there is some apprehension concerning its routine use due to a lack of evidence regarding its safety and side effects.
AIM: To review all available literature reporting the side effects of IV midazolam in children undergoing dental procedures.
DESIGN: Both randomised controlled trials (RCT) and non-randomised studies were reviewed. Reported side effects were categorised as either significant or minor, and the percentage prevalence of significant or minor side effects per episode of treatment was calculated.
RESULTS: Five RCTs were included, in which no significant side events were reported; however, minor side effects were recorded (n = 33, 19.5%), with paradoxical reaction being the most common (n = 11, 6.5%). Six non-randomised studies were included, in which no significant side effects were reported; however, minor side effects were reported (n = 118, 16.8%) with paradoxical reaction being the most common (n = 89, 12.7%).
CONCLUSIONS: Although no significant side effects were recorded, of the minor side effects reported paradoxical reaction was the most common. Due to inconsistency in side effect reporting, the authors suggest the application of a standardised adverse event reporting tool for future studies of sedation in paediatric dentistry.
Arathi Papineni McIntosh; Paul Francis Ashley; Liege Lourenço-Matharu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-11
Journal Detail:
Title:  International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children     Volume:  -     ISSN:  1365-263X     ISO Abbreviation:  Int J Paediatr Dent     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107511     Medline TA:  Int J Paediatr Dent     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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