Document Detail

Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
MedLine Citation:
PMID:  7041027     Owner:  NLM     Status:  MEDLINE    
High dose Methotrexate (HDMtx) is used in the therapy of a broad variety of human tumors. This review reports on completed, ongoing, or planned clinical trials or experience with HDMtx in individual therapy modalities. It is stressed that HDMtx-therapy should solely be given by highly skilled and experienced clinical oncologists, who are able to prevent toxicity and unnecessary side effects by determining Mtx-serum-levels, urine pH, fluid balance and detect clinical indicators for toxicity early enough to escape fatal organ damages.
V Diehl
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Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  Onkologie     Volume:  4     ISSN:  0378-584X     ISO Abbreviation:  Onkologie     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  308-19     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Methotrexate / administration & dosage*,  adverse effects,  therapeutic use
Neoplasms / drug therapy*
Osteosarcoma / drug therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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