Document Detail

Repolarization spatial-time current abnormalities in patients with coronary heart disease.
MedLine Citation:
PMID:  19335862     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Magnetocardiography (MCG) is a new technique for visualizing a current distribution in the myocardium. In recent years, current distribution parameters (CDPs) have been developed based on the distribution. The CDPs reflect spatial-time current abnormalities in patients with coronary heart disease (CHD). However, the criteria and scoring method of the abnormalities using CDPs are still controversial. METHOD: We measured MCG signals for 101 normal controls and 56 CHD patients (single-, double-, and triple-vessel diseases) using a MCG system. The CDPs (maximum current vector [MCV], total current vector [TCV], current integral map, and current rotation) during ventricular repolarization were analyzed. To evaluate the CDPs that are effective in distinguishing between normal controls and CHD patients, the areas under the receiver operating characteristic curve (A(z)) are calculated. Furthermore, the total scores ("0" to "4") of four CDPs with high A(z) values are also calculated. RESULTS: MCV and TCV angles at the T-wave peak had the highest A(z) value. Furthermore, TCV angular differences between the ST-T segment also had high A(z) values. Using the four CDPs, the averaged total score for patients with triple-vessel disease was the highest ("2.67") compared to the other groups (normal controls: 0.53). Furthermore, based on the assumption that subjects with a total score over "1" were suspected of having CHD, sensitivity and specificity were 85.7% and 74.3%, respectively. CONCLUSION: We concluded that the score and criteria using MCV and TCV during repolarization in CHD patients can reflect lesion areas and time changes of electrical activation dispersion due to ischemia.
Kuniomi Ogata; Akihiko Kandori; Yasushi Watanabe; Akihiro Suzuki; Kimio Tanaka; Yuji Oka; Hiroshi Takaki; Hideaki Kanzaki; Satoshi Nakatani; Kunio Miyatake; Shigeyuki Watanabe; Iwao Yamaguchi; Tsuyoshi Miyashita; Shiro Kamakura
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  32     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  516-24     Citation Subset:  IM    
Advanced Research Laboratory, Hitachi Ltd., Higashi-Koigakubo, Kokubunji, Tokyo, Japan.
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MeSH Terms
Arrhythmias, Cardiac / complications,  diagnosis*
Coronary Disease / complications,  diagnosis*
Magnetocardiography / methods*
Middle Aged
Myocardial Ischemia / complications,  diagnosis*
Reproducibility of Results
Sensitivity and Specificity

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