Document Detail


Repolarization changes underlying long-term cardiac memory due to right ventricular pacing: noninvasive mapping with electrocardiographic imaging.
MedLine Citation:
PMID:  22772896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cardiac memory refers to the observation that altered cardiac electrical activation results in repolarization changes that persist after the restoration of a normal activation pattern. Animal studies, however, have yielded disparate conclusions, both regarding the spatial pattern of repolarization changes in cardiac memory and the underlying mechanisms. The present study was undertaken to produce 3-dimensional images of the repolarization changes underlying long-term cardiac memory in humans.
METHODS AND RESULTS: Nine adult subjects with structurally normal hearts and dual-chamber pacemakers were enrolled in the study. Noninvasive electrocardiographic imaging was used before and after 1 month of ventricular pacing to reconstruct epicardial activation and repolarization patterns. Eight subjects exhibited cardiac memory in response to ventricular pacing. In all subjects, ventricular pacing resulted in a prolongation of the activation recovery interval (a surrogate for action potential duration) in the region close to the site of pacemaker-induced activation from 228.4±7.6 ms during sinus rhythm to 328.3±6.2 ms during cardiac memory. As a consequence, increases are observed in both apical-basal and right-left ventricular gradients of repolarization, resulting in a significant increase in the dispersion of repolarization.
CONCLUSIONS: These results demonstrate that electrical remodeling in response to ventricular pacing in human subjects results in action potential prolongation near the site of abnormal activation and a marked dispersion of repolarization. This dispersion of repolarization is potentially arrhythmogenic and, intriguingly, was less evident during continuous right ventricular pacing, suggesting the novel possibility that continuous right ventricular pacing at least partially suppresses pacemaker-induced cardiac memory.
Authors:
Scott B Marrus; Christopher M Andrews; Daniel H Cooper; Mitchell N Faddis; Yoram Rudy
Related Documents :
22124376 - Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have ...
21778596 - Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of hear...
19816976 - Myopathy, left ventricular noncompaction, and tetralogy of fallot.
22717376 - The functional effect of soybean extract and isolated isoflavone on myocardial infarcti...
20071326 - Cocaine-related sudden death: a prospective investigation in south-west spain.
6642936 - Effect of patient imaging angle on apparent cardiac volumes and the potential impact on...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-06
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  5     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-10-26     Revised Date:  2014-08-11    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-81     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Action Potentials
Adult
Aged
Aged, 80 and over
Analysis of Variance
Arrhythmias, Cardiac / diagnosis,  physiopathology,  therapy*
Cardiac Pacing, Artificial*
Electrocardiography
Electrophysiologic Techniques, Cardiac
Equipment Design
Female
Heart Conduction System / physiopathology*
Heart Ventricles / physiopathology*
Humans
Male
Middle Aged
Missouri
Pacemaker, Artificial*
Predictive Value of Tests
Recovery of Function
Time Factors
Grant Support
ID/Acronym/Agency:
R01 HL033343/HL/NHLBI NIH HHS; R01 HL049054/HL/NHLBI NIH HHS; R01-HL-033343-26/HL/NHLBI NIH HHS; R01-HL-049054-18/HL/NHLBI NIH HHS; T32 HL-007275/HL/NHLBI NIH HHS; T32 HL007275/HL/NHLBI NIH HHS; UL1 TR000448/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genome DNA Sequence Variation, Evolution, and Function in Bacteria and Archaea.
Next Document:  Does Location of Epicardial Adipose Tissue Correspond to Endocardial High Dominant Frequency or Comp...