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MedLine Citation:
PMID:  18057510     Owner:  NLM     Status:  In-Data-Review    
We appreciate the interest of Dr Tang in our article. Certainly, our previous results should be taken with caution due to the small database size. Nevertheless, it must be noted that this limitation was clearly recognized in our article. Furthermore, our hypothesis is completely justified from the current state of the art in the analysis of electroencephalogram (EEG) signals from Alzheimer's disease (AD) patients. We evaluated whether the multiscale entropy (MSE) analysis of the EEG background activity was useful to distinguish AD patients and controls. We do believe that further discussions about risk factors or related clinicophysiological protein aspects are clearly beyond the scope of our article. For the sake of completeness, we now detail some results that complement our previous analysis. They suggest that the MSE analysis can provide relevant information about the dynamics of AD patients' EEG data. Thus, we must reaffirm our conclusions, although we again acknowledge that further studies are needed.
J Escudero; D Abásolo; R Hornero; P Espino; M López
Publication Detail:
Type:  Journal Article     Date:  2007-12-03
Journal Detail:
Title:  Physiological measurement     Volume:  28     ISSN:  0967-3334     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  L3-7     Citation Subset:  IM    
Biomedical Engineering Group, ETSI Telecomunicación, University of Valladolid, Camino del Cementerio s/n, 47011, Valladolid, Spain.
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