Document Detail


Replicative homeostasis: a fundamental mechanism mediating selective viral replication and escape mutation.
MedLine Citation:
PMID:  15707489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries, cause an enormous burden of disease and premature death worldwide. These viruses circulate within infected hosts as vast populations of closely related, but genetically diverse, molecules known as "quasispecies". The mechanism(s) by which this extreme genetic and antigenic diversity is stably maintained are unclear, but are fundamental to understanding viral persistence and pathobiology. The persistence of HCV, an RNA virus, is especially problematic and HCV stability, maintained despite rapid genomic mutation, is highly paradoxical. This paper presents the hypothesis, and evidence, that viruses capable of persistent infection autoregulate replication and the likely mechanism mediating autoregulation - Replicative Homeostasis - is described. Replicative homeostasis causes formation of stable, but highly reactive, equilibria that drive quasispecies expansion and generates escape mutation. Replicative homeostasis explains both viral kinetics and the enigma of RNA quasispecies stability and provides a rational, mechanistic basis for all observed viral behaviours and host responses. More importantly, this paradigm has specific therapeutic implication and defines, precisely, new approaches to antiviral therapy. Replicative homeostasis may also modulate cellular gene expression.
Authors:
Richard Sallie
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Publication Detail:
Type:  Journal Article     Date:  2005-02-11
Journal Detail:
Title:  Virology journal     Volume:  2     ISSN:  1743-422X     ISO Abbreviation:  Virol. J.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-02     Completed Date:  2006-09-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101231645     Medline TA:  Virol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  10     Citation Subset:  IM    
Affiliation:
sallier@mac.com
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MeSH Terms
Descriptor/Qualifier:
Antigens, Viral / genetics
Evolution, Molecular
Genetic Variation / genetics
Mutation / genetics*
RNA Viruses / genetics*,  physiology*
Virus Replication / genetics*,  physiology*
Chemical
Reg. No./Substance:
0/Antigens, Viral
Comments/Corrections

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