Document Detail


Replication timing and cell differentiation.
MedLine Citation:
PMID:  11776391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell differentiation may depend in part upon a type of unbalanced growth in which several cell cycles occur with a reduced level of total protein synthesis. During this period the synthesis of the chromatin protein HMG-I/Y is reduced since its synthesis is correlated with that of total protein. The synthesis of histone H1 shows less reduction since its synthesis is entrained with that of DNA. This greater reduction of HMG-I/Y than of histone H1 is thought to delay or prevent replicon initiations within AT-enriched isochores. This shifts their time of replication from early to late S phase. This may restrict certain pathways of cell differentiation in multipotent progenitor cells and allow one particular type of differentiation.
Authors:
R Flickinger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  69     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-03     Completed Date:  2002-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  18-26     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, State University of New York at Buffalo, 14260, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation*
DNA / biosynthesis,  chemistry
DNA Replication*
HMGA1a Protein / physiology
Heterochromatin / physiology
Histones / physiology
Replicon*
Chemical
Reg. No./Substance:
0/Heterochromatin; 0/Histones; 124544-67-8/HMGA1a Protein; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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