| Replication timing and cell differentiation. | |
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MedLine Citation:
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PMID: 11776391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell differentiation may depend in part upon a type of unbalanced growth in which several cell cycles occur with a reduced level of total protein synthesis. During this period the synthesis of the chromatin protein HMG-I/Y is reduced since its synthesis is correlated with that of total protein. The synthesis of histone H1 shows less reduction since its synthesis is entrained with that of DNA. This greater reduction of HMG-I/Y than of histone H1 is thought to delay or prevent replicon initiations within AT-enriched isochores. This shifts their time of replication from early to late S phase. This may restrict certain pathways of cell differentiation in multipotent progenitor cells and allow one particular type of differentiation. |
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Authors:
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R Flickinger |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Differentiation; research in biological diversity Volume: 69 ISSN: 0301-4681 ISO Abbreviation: Differentiation Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-01-03 Completed Date: 2002-05-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401650 Medline TA: Differentiation Country: Germany |
Other Details:
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Languages: eng Pagination: 18-26 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, State University of New York at Buffalo, 14260, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation* DNA / biosynthesis, chemistry DNA Replication* HMGA1a Protein / physiology Heterochromatin / physiology Histones / physiology Replicon* |
| Chemical | |
Reg. No./Substance:
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0/Heterochromatin; 0/Histones; 124544-67-8/HMGA1a Protein; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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