Document Detail


Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction.
MedLine Citation:
PMID:  19030008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity. DESIGN: We examined the effect of this FTO variant on BMI in 3353 Australian adult male and female twins. RESULTS: The minor A allele of rs9939609 was associated with an increased BMI (P=0.0007). Each additional copy of the A allele was associated with a mean BMI increase of approximately 1.04 kg/m(2) (approximately 3.71 kg). Using variance components decomposition, we estimate that this single-nucleotide polymorphism accounts for approximately 3% of the genetic variance in BMI in our sample (approximately 2% of the total variance). By comparing intrapair variances of monozygotic twins of different genotypes we were able to perform a direct test of gene by environment (G x E) interaction in both sexes and gene by parity (G x P) interaction in women, but no evidence was found for either. CONCLUSIONS: In addition to supporting earlier findings that the rs9939609 variant in the FTO gene is associated with an increased BMI, our results indicate that the associated genetic effect does not interact with environment or parity.
Authors:
B K Cornes; P A Lind; S E Medland; G W Montgomery; D R Nyholt; N G Martin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2008-11-25
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  33     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia. belinda.cornes@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Australia
Body Mass Index
Chi-Square Distribution
Europe / ethnology
Female
Gene Expression
Genetic Predisposition to Disease
Genotype
Homozygote
Humans
Life Style
Likelihood Functions
Male
Middle Aged
Obesity / genetics*
Parity
Polymorphism, Single Nucleotide*
Pregnancy
Proteins / genetics*
Sex Factors
Twins / genetics*
Grant Support
ID/Acronym/Agency:
AA 07535/AA/NIAAA NIH HHS; AA 07728/AA/NIAAA NIH HHS; AA 10249/AA/NIAAA NIH HHS; DA 00272/DA/NIDA NIH HHS; DA 07261/DA/NIDA NIH HHS; MH 14677/MH/NIMH NIH HHS; MH 17104/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/FTO protein, human; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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