Document Detail


Replication needed to distinguish alterations in cell ratios, the frequency of individual stages of the cycle of the seminiferous epithelium, or the appearance of abnormalities in the testes of rodents, rabbits, or humans.
MedLine Citation:
PMID:  20133966     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The typical levels of inherent variability among untreated sexually mature rodents, rabbits, or men were determined for several endpoints used to characterize spermatogenesis. The latter included germ cell:germ cell and germ cell:Sertoli cell ratios, the frequency of specific stages of the cycle of the seminiferous epithelium, and the appearance of a variety of testicular abnormalities. Based on this variability, the number of replicates needed to provide future experiments of a predictable power and sensitivity was estimated. Replication requirements differed greatly as a function of species and/or among specific endpoints within a single species. In addition, the replication needed to provide robust experiments was substantially greater than that employed in most investigations. The application of these findings during the design and interpretation of future experiments was discussed.
Authors:
William E Berndtson
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Publication Detail:
Type:  Journal Article     Date:  2010-02-04
Journal Detail:
Title:  Journal of andrology     Volume:  31     ISSN:  1939-4640     ISO Abbreviation:  J. Androl.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-606     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of New Hampshire, Durham, NH 03824, USA. bill.berndtson@unh.edu
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