Document Detail


Replicating viruses as selective cancer therapeutics.
MedLine Citation:
PMID:  9015793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Replication-competent viruses are used as selective cancer therapeutics and the mechanisms leading to tumor-specific replication and antitumoral efficacy are now becoming apparent. The specific viruses in development include tumor-targeting herpes simplex viruses, autonomous parvoviruses, Newcastle disease viruses and adenovirus. Information is also available on antiviral immunology and viral defenses against host-mediated immunity. This approach has many potential attributes, in addition to potential hurdles that must be overcome.
Authors:
D H Kirn; F McCormick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular medicine today     Volume:  2     ISSN:  1357-4310     ISO Abbreviation:  Mol Med Today     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-07     Completed Date:  1997-04-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9508560     Medline TA:  Mol Med Today     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  519-27     Citation Subset:  IM    
Affiliation:
Director of Pre-clinical and Clinical Research, ONYX Pharmaceuticals, Richmond, CA 94806, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenoviruses, Human / immunology,  physiology
Animals
Genetic Vectors / immunology
Humans
Neoplasms / therapy*
Newcastle disease virus / immunology,  physiology
Parvovirus / immunology,  physiology
Simplexvirus / immunology,  physiology
Viral Proteins / immunology
Virus Physiological Phenomena*
Virus Replication*
Chemical
Reg. No./Substance:
0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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