Document Detail

Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly.
MedLine Citation:
PMID:  22561213     Owner:  NLM     Status:  MEDLINE    
The centromere is the fundamental unit for insuring chromosome inheritance. This complex region has a distinct type of chromatin in which histone H3 is replaced by a structurally different homologue identified in humans as CENP-A. In metazoans, specific DNA sequences are neither required nor sufficient for centromere identity. Rather, an epigenetic mark comprised of CENP-A containing chromatin is thought to be the major determinant of centromere identity. In this view, CENP-A deposition and chromatin assembly are fundamental processes for the maintenance of centromeric identity across mitotic and meiotic divisions. Several lines of evidence support CENP-A deposition in metazoans occurring at only one time in the cell cycle. Such cell cycle-dependent loading of CENP-A is found in divergent species from human to fission yeast, albeit with differences in the cell cycle point at which CENP-A is assembled. Cell cycle dependent CENP-A deposition requires multiple assembly factors for its deposition and maintenance. This review discusses the regulation of new CENP-A deposition and its relevance to centromere identity and inheritance.
Yael Nechemia-Arbely; Daniele Fachinetti; Don W Cleveland
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-27
Journal Detail:
Title:  Experimental cell research     Volume:  318     ISSN:  1090-2422     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-08-23     Revised Date:  2013-07-17    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1353-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
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MeSH Terms
Autoantigens / metabolism*,  physiology
Centromere / genetics*,  metabolism
Chromatin / genetics*,  metabolism
Chromosomal Proteins, Non-Histone / metabolism*,  physiology
DNA Replication / genetics,  physiology*
Models, Biological
Protein Multimerization / genetics*,  physiology
Signal Transduction / genetics,  physiology
Time Factors
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Autoantigens; 0/Chromatin; 0/Chromosomal Proteins, Non-Histone; 0/centromere protein A

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