Document Detail

Repletion of n-3 fatty acid deficient dams with alpha-linolenic acid: effects on fetal brain and liver fatty acid composition.
MedLine Citation:
PMID:  20625936     Owner:  NLM     Status:  MEDLINE    
Docosahexaenoic acid (DHA) supply to the fetal brain depends upon the dam's dietary intake of n-3 fats. In this study, we measured the incorporation of DHA into the fetal brain and liver in n-3 fatty acid deficient (0.1% alpha-linolenate) mice upon switching to an n-3 fatty acid adequate (2.1% alpha-linolenate) diet. Second generation mice raised and maintained on an n-3 deficient diet during mating were switched to an n-3 adequate diet on embryonic day 1 (ED 1) or ED 13. Fatty acid analysis was performed on fetal brains and livers and on maternal serum on ED 13, 15, 17, and 19. Although fetal brain and liver DHA began at a very low level (both exhibited an 85% decline), recovery was nearly complete by ED 15 in the group switched near conception but thereafter diverged. The maternal serum and fetal liver were very similar in their DHA and docosapentaenoic acid time courses. However, when repletion began on ED 13, brain DHA recovery was only about 44%. These results suggest that a nutritional intervention with alpha-linolenic acid can nearly but incompletely rescue the mouse fetal DHA deficiency if began at the time of conception but that the third trimester is too late, thus leaving a large DHA gap.
Akiko Harauma; Norman Salem; Toru Moriguchi
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Publication Detail:
Type:  Journal Article     Date:  2010-07-13
Journal Detail:
Title:  Lipids     Volume:  45     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  659-68     Citation Subset:  IM    
Healthcare Research Institute, Wakunaga Pharmaceutical Co. Ltd, Hiroshima, Japan.
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MeSH Terms
Brain / metabolism*
Chromatography, Gas
Dietary Fats / administration & dosage,  metabolism
Fatty Acids, Omega-3 / metabolism*
Fetus / metabolism*
Liver / metabolism*
alpha-Linolenic Acid / administration & dosage,  metabolism*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3; 463-40-1/alpha-Linolenic Acid

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