Document Detail


Replacing short-acting nifedipine with alternative medications at a large health maintenance organization.
MedLine Citation:
PMID:  9607386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In response to recent evidence about the safety of calcium channel blockers, Group Health Cooperative of Puget Sound (GHC), a large health maintenance organization, implemented a plan in April 1996 to reevaluate the medications of 1349 patients who were taking short-acting nifedipine. Following the intervention, 79.8% of patients taking short-acting nifedipine discontinued use, and 45.6% switched to once-daily felodipine. By presenting physicians and patients with recent evidence about the safety of short-acting nifedipine, a large health maintenance organization was able to motivate broad-scale changes to safer alternative drug therapies.
Authors:
R C Kaplan; B M Psaty; D Kriesel; S R Heckbert; N L Smith; C Gillett; A G Golston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  11     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-27     Completed Date:  1998-07-27     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM    
Affiliation:
Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle 98101, USA. rkaplan@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Calcium Channel Blockers / adverse effects*,  therapeutic use
Cohort Studies
Delayed-Action Preparations
Drug Utilization / trends
Felodipine / administration & dosage,  therapeutic use*
Female
Follow-Up Studies
Health Maintenance Organizations*
Humans
Hypertension / drug therapy*
Male
Nifedipine / adverse effects*,  therapeutic use
Retreatment
Safety
Grant Support
ID/Acronym/Agency:
AG09556/AG/NIA NIH HHS; HL40628/HL/NHLBI NIH HHS; HL43201/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Delayed-Action Preparations; 21829-25-4/Nifedipine; 72509-76-3/Felodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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