Document Detail

Replacement of protease inhibitors by nevirapine or efavirenz in simplification and rescue interventions: which works better?
MedLine Citation:
PMID:  12916009     Owner:  NLM     Status:  MEDLINE    
The outcome of 162 patients replacing protease inhibitors (PIs) by nonnucleoside reverse transcriptase inhibitors (NNRTIs) was retrospectively assessed. After 48 weeks of follow-up, nevirapine (NVP) and efavirenz (EFV) performed similarly well in simplification interventions in patients with undetectable viremia, while EFV provided significantly better results in rescue interventions after PI failure. Previous suboptimal exposure to nucleoside analogs conditioned lower chances of virologic success using either NVP or EFV. Both drugs were generally well tolerated, although specific toxicities could make one drug more suitable than the other for certain patients.
Pablo Barreiro; Nuria Camino; Rosa De Julián; Juan González-Lahoz; Vincent Soriano
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  HIV clinical trials     Volume:  4     ISSN:  1528-4336     ISO Abbreviation:  HIV Clin Trials     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-13     Completed Date:  2004-03-17     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  100936377     Medline TA:  HIV Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
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MeSH Terms
HIV Infections / drug therapy*,  virology
HIV Protease Inhibitors / administration & dosage*,  adverse effects,  therapeutic use*
HIV-1 / drug effects,  physiology
Middle Aged
Nevirapine / administration & dosage*,  adverse effects,  therapeutic use*
Oxazines / administration & dosage*,  adverse effects,  therapeutic use*
Retrospective Studies
Reverse Transcriptase Inhibitors / administration & dosage,  adverse effects,  therapeutic use
Salvage Therapy*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Benzoxazines; 0/HIV Protease Inhibitors; 0/Oxazines; 0/Reverse Transcriptase Inhibitors; 99DK7FVK1H/Nevirapine; JE6H2O27P8/efavirenz

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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