Document Detail

Replacement of the anterior cruciate ligament with a bone-ligament-bone anterior cruciate ligament allograft in dogs.
MedLine Citation:
PMID:  3555926     Owner:  NLM     Status:  MEDLINE    
Acute replacement of the canine anterior cruciate ligament (ACL) with a frozen, bone-ligament-bone anterior cruciate ligament preparation was studied using biochemical, immunologic, and biomechanical testing methods. Nine dogs were used for the study, six dogs received allografts and three received autografts. No tissue antigen matching was performed. All nine dogs were killed nine months after surgery. Necropsy examination revealed that the ACL was not present in three joints (one autograft, two allografts). The two autograft and four allograft ligaments available for mechanical testing sustained mean maximum loads that were 10% and 14%, respectively, of the mean maximum loads sustained by the contralateral ACL. Autoradiography indicated that cellular activity was more pronounced in the autograft specimens. Hydroxyproline uptake was 200% and 45% of normal in the autograft and allograft ligaments, respectively. Both autograft and allograft specimens were producing Type I collagen at the time of killing. Antidonor dog leukocyte antigen (DLA) antibody was detected in the synovial fluid taken at the time of killing from six of six dogs that received allografts and in zero of three dogs that received autografts.
P B Vasseur; J J Rodrigo; S Stevenson; G Clark; N Sharkey
Related Documents :
1262366 - Tension studies of human knee ligaments. yield point, ultimate failure, and disruption ...
10569486 - Pt-12, a putative ras-activated proliferation-dependent gene, is expressed in patellar ...
19122096 - A comprehensive review of partial anterior cruciate ligament tears.
9665686 - Isometry of the anterior cruciate ligament: an intraoperative perspective.
16132986 - Plate augmentation leaving the nail in situ and bone grafting for non-union of femoral ...
10941396 - A trans stt, trans capitate perilunate dislocation of the carpus. a case report.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-06     Completed Date:  1987-07-06     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-77     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibodies / analysis
Bone Transplantation*
Hydroxyproline / analysis
Knee Joint / surgery*
Leukocytes / immunology
Ligaments / analysis,  transplantation*
Preservation, Biological
Transplantation Immunology
Transplantation, Homologous
Reg. No./Substance:
0/Antibodies; 51-35-4/Hydroxyproline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nonunion of the humeral shaft.
Next Document:  Contractures. A historical perspective.